Abstract
The sequence A–A–U–A–A–A is present in six different purified messenger RNA molecules (specifically the α- and β-globulin mRNAs of rabbit and human, the immunoglobulin light chain mRN A of mouse (MOPC 21) and the ovalbumin mRN A of chicken) about 20 residues away from the 3′-terminal poly(A) sequence. In addition, a large selection of the 3′ non-coding regions of rabbit and human globin mRN As (both the α- and β- globin mRN As) are 85% homologous, demonstrating that this region is significantly conserved in evolution.
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Proudfoot, N., Brownlee, G. 3′ Non-coding region sequences in eukaryotic messenger RNA. Nature 263, 211–214 (1976). https://doi.org/10.1038/263211a0
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DOI: https://doi.org/10.1038/263211a0
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