Abstract
IT is well established that human cells which are trisomic for chromosome 21 are more sensitive to the antiviral activity of interferon than normal diploid cells1–6. If chromosome 21 codes for an interferon receptor site localised at the cell surface, as suggested4,5, one might expect cellular binding of interferon to increase in the order mono-somic 21 cells, disomic 21 cells and trisomic 21 cells. This did not prove to be the case. All cell types bound interferon equally well. In view of these and previously5 reported data, it is postulated that chromosome 21, if it codes for a protein involved in the interferon response of the cells, does not specify the receptor molecule per se but another molecule that is involved in the processing of the antiviral message from the cell surface to the interior of the cell.
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DE CLERCQ, E., EDY, V. & CASSIMAN, JJ. Chromosome 21 does not code for an interferon receptor. Nature 264, 249–251 (1976). https://doi.org/10.1038/264249a0
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DOI: https://doi.org/10.1038/264249a0
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