Abstract
THE development of the central nervous system is characterised by the formation of specific synaptic connections. Highly selective connections form not only between classes of neurones, but also between specific neurones within classes. An additional degree of specificity is observed when the presynaptic axons contact only a limited portion of the target neurone. This kind of specificity is conspicuous in the dentate gyrus (fascia dentata) of the mammalian cerebral cortex. We describe here a situation in which the dentate gyrus offers a unique opportunity to test some of the hypotheses that may explain the selective termination of different afferents on restricted portions of the surface of a neurone.
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LAURBERG, S., HJORTH-SIMONSEN, A. Growing central axons deprived of normal target neurones by neonatal X-ray irradiation still terminate in a precisely laminated fashion. Nature 269, 158–160 (1977). https://doi.org/10.1038/269158a0
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DOI: https://doi.org/10.1038/269158a0
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