Abstract
PREVIOUS studies have given mainly indirect1,2, and some direct3,4 evidence that the mobility of surface membrane receptors may be controlled by cytoplasmic microfilaments and microtubules. It has been proposed1,2 that the receptor–cytoskeletal complex may have important roles in cell–cell recognition, cell motility and cell division. This study, using two fluorochromes to identify concanavalin A (con A) receptors and cytoplasmic actin in the same cell, shows that con A binding to neoplastic and embryonic cell surfaces results in dissolution of actin filaments and that con A receptors and actin co-cap and occur in closely related sites in untreated and cytochalasin B-treated cells.
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TOH, B., HARD, G. Actin co-caps with concanavalin A receptors. Nature 269, 695–697 (1977). https://doi.org/10.1038/269695a0
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DOI: https://doi.org/10.1038/269695a0
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