Abstract
HISTAMINE is generally thought to act as a neurotransmitter in the central nervous system (see, for example, ref. 1). Electrophysiological2 and biochemical3 studies have indicated that both H1- and H2-receptors are present in the brain. Functionally, histamine has been implicated in central mechanisms of thirst4 and thermoregulation5. A role for brain histamine in tolerance and physical dependence to morphine has also been suggested6,7. We describe here studies in which we microinjected histamine into various regions of the rat brain and observed analgesia and catalepsy from periaqueductal sites and effects resembling symptoms of morphine withdrawal from sites in the hippocampus.
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GLICK, S., CRANE, L. Opiate-like and abstinence-like effects of intracerebral histamine administration in rats. Nature 273, 547–549 (1978). https://doi.org/10.1038/273547a0
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DOI: https://doi.org/10.1038/273547a0
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