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Release of vasoactive intestinal polypeptide in mast cells by histamine liberators

Nature volume 275, pages 661–662 (1978)Cite this article

Abstract

VASOACTIVE INTESTINAL POLYPEPTIDE (VIP), originally isolated from porcine duodenum1, is a potent relaxant of vascular and nonvascular smooth muscle2, and a stimulant of adenylate cyclase activity3,4. The peptide has been localised in endocrine cells in the gastrointestinal tract and pancreatic islets5,6, as well as in nervous structures in these and other organs7–9, the peripheral autonomic nervous system and selected areas of the brain8–11. We report here immunological evidence that VIP, or a closely related peptide, occurs in mast cells, from which it can be released by compound 48/80 or by the Ca2+ ionophore A23187.

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Authors and Affiliations

  1. Department of Pathology and Research Institute, The Hospital for Sick Children, Toronto

    ERNEST CUTZ, WILSON CHAN & NORMAN S. TRACK

  2. Departments of Surgery and Clinical Biochemistry, University of Toronto and Mount Sinai Hospital, Toronto, Canada

    ERNEST CUTZ, WILSON CHAN & NORMAN S. TRACK

  3. Departments of Pharmacology and Internal Medicine, University of Texas Southwestern Medical School, Dallas

    ANDRES GOTH & SAMI I. SAID

  4. Veterans Administration Hospital, Dallas, Texas

    ANDRES GOTH & SAMI I. SAID

Authors
  1. ERNEST CUTZ
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  2. WILSON CHAN
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  3. NORMAN S. TRACK
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  4. ANDRES GOTH
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  5. SAMI I. SAID
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CUTZ, E., CHAN, W., TRACK, N. et al. Release of vasoactive intestinal polypeptide in mast cells by histamine liberators. Nature 275, 661–662 (1978). https://doi.org/10.1038/275661a0

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