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The amino acid sequence of the α-chain of human fibrinogen

Abstract

The amino acid sequence of the human fibrinogen α-chain reveals a structure that can be divided into three zones of unique amino acid composition. The middle of these contains the two primary α-chain cross-linking acceptor sites and consists of a remarkable series of internal duplications.

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References

  1. McKee, P. A., Rogers, L. A., Marler, E. & Hill, R.L. Archs Biochem. Biophys. 116, 271–279 (1966).

    Article  CAS  Google Scholar 

  2. Gaffney, P. J. Biochim. biophys. Acta 263, 453–458 (1972).

    Article  CAS  Google Scholar 

  3. Pizzo, S. V., Schwartz, M. L., Hill, R. L. & McKee, P. A. J. biol. Chem. 247, 636–645 (1972).

    CAS  PubMed  Google Scholar 

  4. Blomback, B., Hessel, B., Iwanaga, S., Reuterby, J. & Blomback, M. J. biol. Chem. 247, 1496–1512 (1972).

    CAS  PubMed  Google Scholar 

  5. Takagi, T. & Doolittle, R. F. Biochemistry 14, 5146–5149 (1975); Thromb. Res. 7, 813–818 (1975).

    Google Scholar 

  6. Gårdlund, B. Thromb. Res. 10, 689–702 (1977).

    Article  Google Scholar 

  7. Doolittle, R. F. et al. Biochemistry 16, 1703–1709, 1710–1715 (1977).

    Article  CAS  Google Scholar 

  8. Cottrell, B. A. & Doolittle, R. F. Biochem. biophys. Res. Commun. 71, 745–761 (1976); Thromb. Res. 12, 1135–1146 (1978).

    Article  Google Scholar 

  9. Lottspeich, F. & Henschen, A. Hoppe–Seyler's Z. physiol. Chem. 359, 1451–1455, 1611–1616 (1978).

    CAS  PubMed  Google Scholar 

  10. Doolittle, R. F., Cottrell, B. A., Strong, D. & Watt, K. W. K. Thromb. Res. 14, 787–792 (1979).

    Article  CAS  Google Scholar 

  11. Doolittle, R. F., Goldbaum, D. M. & Doolittle, L. R. J. molec. Biol. 120, 311–325 (1978).

    Article  CAS  Google Scholar 

  12. Garnier, J., Osguthorpe, D. J. & Robson, B. J. molec. Biol. 120, 97–120 (1978).

    Article  CAS  Google Scholar 

  13. Doolittle, R. F. et al. in Chemistry and Physiology of Plasma Proteins (Pergamon, New York, in the press).

  14. Gaffney, P. J. in Haemostasis: Biochemistry, Physiology and Pathology (eds Ogston, D. & Bennett, B.) 105–168 (John Wiley, London, 1977).

    Google Scholar 

  15. Nussenzweig, V. et al. Annls Inst. Pasteur, Paris 100, 377–389 (1961).

    CAS  Google Scholar 

  16. Chen, R. & Doolittle, R. F. Proc. natn. Acad. Sci. U.S.A. 63, 420–427 (1969); 66, 472–479 (1970); Biochemistry 10, 4486–4491 (1971).

    Article  ADS  CAS  Google Scholar 

  17. McKee, P. A., Mattock, P. & Hill, R. L. Proc. natn. Acad. Sci. U.S.A. 66, 738–744 (1970).

    Article  ADS  CAS  Google Scholar 

  18. Mosher, D. F. J. biol. Chem. 250, 6614–6621 (1975).

    CAS  PubMed  Google Scholar 

  19. Ruoslahti, E. & Vaheri, A. J. exp. Med. 141, 497–501 (1975).

    Article  CAS  Google Scholar 

  20. Brinkhous, K. W., Read, M. S. & Mason, R. G. Lab. Invest. 14, 335–342 (1965).

    CAS  PubMed  Google Scholar 

  21. Duthie, E. S. J. gen. Microbiol. 10, 427–436 (1954).

    Article  CAS  Google Scholar 

  22. Budzynski, A. Z., Joseph, R. T., Olexa, S. A. & Niewiarowski, S. Fedn Proc. 38, 996 abstr. (1979).

  23. Hawinger, J. et al. (in preparation).

  24. Mosesson, M. W. Ann. N. Y. Acad. Sci. 312, 11–30 (1979).

    Article  ADS  Google Scholar 

  25. Doolittle, R. F. Adv. Protein Chem. 27, 1–109 (1973).

    Article  CAS  Google Scholar 

  26. Weisel, J. W., Warren, S. G. & Cohen, C. J. molec. Biol. 126, 159–183 (1978).

    Article  CAS  Google Scholar 

  27. Mosesson, M. W., Umfleet, R. A., Finlayson, J. S. & Galanakis, D. K. J. biol. Chem. 247, 5210–5219 (1972).

    CAS  PubMed  Google Scholar 

  28. Doolittle, R. F. Fedn Proc. 35, 2145–2149 (1976).

    CAS  Google Scholar 

  29. Henschen, A. & Lottspeich, F. Thromb. Res. 11, 869–880 (1977).

    Article  CAS  Google Scholar 

  30. Watt, K. W. K., Takagi, T. & Doolittle, R. F. Proc. natn. Acad. Sci. U.S.A. 75, 1731–1735 (1978).

    Article  ADS  CAS  Google Scholar 

  31. Blomback, B. et al. J. biol. Chem. 248, 5806–5820 (1973).

    CAS  PubMed  Google Scholar 

  32. Sharp, J. J., Cassman, K. G. & Doolittle, R. F. FEBS Lett. 24, 334–336 (1972).

    Article  Google Scholar 

  33. Takagi, T. & Doolittle, R. F. Biochemistry 14, 940–946 (1975).

    Article  CAS  Google Scholar 

  34. Henschen, A. & Lottspeich, F. Hoppe–Seyler's Z. physiol. Chem. 358, 935–938 (1977).

    PubMed  Google Scholar 

  35. Blomback, B., Hessel, B. & Hogg, D. Thromb. Res. 8, 639–658 (1976).

    Article  CAS  Google Scholar 

  36. Henschen, A. & Lottspeich, F. Hoppe–Seyler's Z. physiol. Chem. 358, 1643–1646 (1977).

    CAS  PubMed  Google Scholar 

  37. Watt, K. W. K., Takagi, T. & Doolittle, R. F. Biochemistry 18, 68–76 (1979).

    Article  CAS  Google Scholar 

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Doolittle, R., Watt, K., Cottrell, B. et al. The amino acid sequence of the α-chain of human fibrinogen. Nature 280, 464–468 (1979). https://doi.org/10.1038/280464a0

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