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Chicken ovalbumin contains an internal signal sequence

Nature volume 281, pages 117–121 (1979)Cite this article

Abstract

Ovalbumin is shown to contain an internal rather than an amino-terminal signal sequence. This internal signal can be recovered in a tryptic fragment which comprises residues 229–276 of mature ovalbumin and contains a region of striking sequence homology to amino-terminal cleaved signals of two other oviduct secretory proteins. The isolated tryptic fragment is used as a probe to demonstrate that a signal receptor is present in membrane vesicles derived from the rough but not in those derived from the smooth endoplasmic reticulum.

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Authors and Affiliations

  1. Laboratory of Cell Biology, The Rockefeller University, New York, New York, 10021

    Vishwanath R. Lingappa, Jaisri R. Lingappa & Günter Blobel

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  1. Vishwanath R. Lingappa
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  2. Jaisri R. Lingappa
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  3. Günter Blobel
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Lingappa, V., Lingappa, J. & Blobel, G. Chicken ovalbumin contains an internal signal sequence. Nature 281, 117–121 (1979). https://doi.org/10.1038/281117a0

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