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Influence of H–2 complex on acquired resistance to Leishmania donovani infection in mice

Nature volume 283, pages 72–74 (1980)Cite this article

Abstract

Innate susceptibility to Leishmania donovani infection in mice (measured over 2–4 weeks) is under the control of a single autosomal gene (Lsh) segregating for incompletely dominant resistant (r) and recessive susceptible (s) alleles1. This locus maps2 away from the known histocompatibility loci to a position between the centromere and Id–1 on the chromosome 1 of the mouse. Amongst homozygous recessive Lshs strains of mice two patterns of recovery are observed3 when the course of infection is followed over a longer term. In some strains a dramatic fall in parasite numbers with histological liver damage occurs while other strains maintain immense parasite loads for up to two years involving mononuclear phagocytes throughout the body. We now present evidence which suggests that this difference in long-term response is largely controlled by a gene(s) within, or closely adjacent to, the major histocompatibility complex (H–2) of the mouse.

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References

  1. Bradley, D. J. Clin. exp. Immun. 30, 130–140 (1977).

    CAS  PubMed  Google Scholar 

  2. Bradley, D. J., Taylor, B. A., Blackwell, J., Evans, E. P. & Freeman, J. Clin. exp. Immun. 37, 7–14 (1979).

    CAS  PubMed  Google Scholar 

  3. Bradley, D. J. & Kirkley, J. Clin. exp. Immun. 30, 119–129 (1977).

    CAS  PubMed  Google Scholar 

  4. Stauber, L. A. in Some Physiological Aspects and Consequences of Parasitism 76–90 (Rutgers University Press, New Brunswick, 1955).

    Google Scholar 

  5. Festenstein, H. et al. in Histocompatibility Testing (eds Dausset, J. & Colombani, J.) 175–178 (Munksgaard, Copenhagen, 1972).

    Google Scholar 

  6. Lilly, F. Genetics 53, 529–539 (1966).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Chesebro, B., Wehrly, K. & Stimpfling, J. J. exp. Med. 140, 1457–1467 (1974).

    Article  CAS  Google Scholar 

  8. Lonai, P. & Haran-Ghera, N. J. exp. Med. 146, 1164–1168 (1977).

    Article  CAS  Google Scholar 

  9. Stauber, L. A. Rice Inst. Pamph. 45, 80–96 (1958).

    Google Scholar 

  10. Benacerraf, B. & McDevitt, H. O. Science 175, 273–279 (1972).

    Article  CAS  ADS  Google Scholar 

  11. Whitmore, A. C. & Haughton, G. Immunogenetics 2, 379–388 (1975).

    Article  Google Scholar 

  12. Tucker, H. S. G. et al. J. Immun. 118, 1239–1243 (1977).

    CAS  PubMed  Google Scholar 

  13. Chesebro, B. & Wehrly, K. J. Immun. 120, 1081–1085 (1978).

    CAS  PubMed  Google Scholar 

  14. Kapp, J. A., Pierce, C. W., Schlossman, S. & Benacerraf, B. J. exp. Med. 140, 648–659 (1974).

    Article  CAS  Google Scholar 

  15. Debre, P., Kapp, J. A., Dorf, M. E. & Benacerraf, B. J. exp. Med. 142, 1447–1454 (1975).

    Article  CAS  Google Scholar 

  16. Meruelo, D., Deak, B. & McDevitt, H. O. J. exp. Med. 146, 1367–1379 (1977).

    Article  CAS  Google Scholar 

  17. Freedman, H. A., Lilly, F., Strand, M. & August, J. T. Cell 13, 33–40 (1978).

    Article  CAS  Google Scholar 

  18. Zinkernagel, R. M. et al. J. exp. Med. 145, 1353–1367 (1977).

    Article  CAS  Google Scholar 

  19. Zinkernagel, R. M. & Doherty, P. C. J. exp. Med. 141, 1427–1436 (1975).

    Article  CAS  Google Scholar 

  20. de Vries, R. R. P., Lai A Fat, R. F. M., Nijenhuis, L. E. & van Rood, J. J. Lancet ii, 1328–1330 (1976).

    Article  Google Scholar 

  21. Fine, P. E. M. et al. J. infect. Dis. 140, 152–161 (1979).

    Article  CAS  Google Scholar 

  22. Piazza, A., Belvedere, M. C., Bernoco, D. & Cepellini, R. in Histocompatibility Testing (eds Dausset, J. & Colombani, J.) 73–78 (Munksgaard, Copenhagen, 1972).

    Google Scholar 

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Authors and Affiliations

  1. Ross Institute of Tropical Hygiene, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1

    Jenefer Blackwell, Joan Freeman & David Bradley

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  1. Jenefer Blackwell
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  2. Joan Freeman
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  3. David Bradley
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Blackwell, J., Freeman, J. & Bradley, D. Influence of H–2 complex on acquired resistance to Leishmania donovani infection in mice. Nature 283, 72–74 (1980). https://doi.org/10.1038/283072a0

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