Abstract
Deletions spanning portions of the heavy chain constant region (CH) locus in murine plasmacytomas are revealed by hybridization with cloned immunoglobulin DNA molecules. The pattern of deletions suggests that a lymphocyte clone switches expression of CH genes by successive deletions and that the probable CH gene order is 5′ µ-γ3-γ1-γ2b-γ2a-α3′.
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Cory, S., Jackson, J. & Adams, J. Deletions in the constant region locus can account for switches in immunoglobulin heavy chain expression. Nature 285, 450–456 (1980). https://doi.org/10.1038/285450a0
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DOI: https://doi.org/10.1038/285450a0
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