Abstract
Malaria is increasing in incidence and prevalence in most tropical areas and is a major problem for both individuals and communities1. Current malaria research is aimed at developing vaccines2–4 and, for this, it may be useful to define Plasmodium antigen(s) related to the development of a protective immune response in the host. Monoclonal antibodies have recently been shown to interfere with rodent malaria infection (Plasmodium berghei) at the sporozoite5 or merozoite6 stage. We have now raised monoclonal antibodies againstsingle antigenic determinant(s) of Plasmodium falciparum and report that some of them inhibit the growth of erythrocytic forms of P. falciparum in vitro.
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Perrin, L., Ramirez, E., Lambert, P. et al. Inhibition of P. falciparum growth in human erythrocytes by monoclonal antibodies. Nature 289, 301–303 (1981). https://doi.org/10.1038/289301a0
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DOI: https://doi.org/10.1038/289301a0
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