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Sequence homology and structural comparison between the chromosomal human α1-antitrypsin and chicken ovalbumin genes

Nature volume 297, pages 655–659 (1982)Cite this article

Abstract

The human chromosomal α1-antitrypsin gene has been cloned. This gene is approximately 5 kilobase pairs long and contains three intervening sequences in the peptide-coding region. DNA sequences coding for the amino and carboxyl termini of α1-antitrypsin have been identified. Human α1-antitrypsin and chicken ovalbumin show significant sequence homology and belong to a common protein super-family. Yet the number, position and size of intervening sequences reveal that the two genes are dissimilar.

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Author notes

  1. George L. Long, Kotoku Kurachi and Earl W. Davie: Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA

Authors and Affiliations

  1. Howard Hughes Medical Institute Laboratory, Department of Cell Biology, Baylor College of Medicine, Houston, Texas, 77030, USA

    Margaret Leicht, George L. Long, T. Chandra, Kotoku Kurachi, Vincent J. Kidd, Myles Mace Jr, Earl W. Davie & Savio L. C. Woo

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  1. Margaret Leicht
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  2. George L. Long
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  3. T. Chandra
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  4. Kotoku Kurachi
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  8. Savio L. C. Woo
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Leicht, M., Long, G., Chandra, T. et al. Sequence homology and structural comparison between the chromosomal human α1-antitrypsin and chicken ovalbumin genes. Nature 297, 655–659 (1982). https://doi.org/10.1038/297655a0

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