Abstract
The amino acid sequences of the repressor and cro proteins of phages λ, 434 and P22 are homologous, especially in a region in which repressor and λ cro have a similar α-helix–turn–α-helix secondary structure. Model-building studies indicate that this structure is important in DNA binding, and we suggest it may be a common feature of many DNA-binding proteins.
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Sauer, R., Yocum, R., Doolittle, R. et al. Homology among DNA-binding proteins suggests use of a conserved super-secondary structure. Nature 298, 447–451 (1982). https://doi.org/10.1038/298447a0
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DOI: https://doi.org/10.1038/298447a0
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