Abstract
We have identified a serotonin-sensitive K+ channel with novel properties. The channel is active at the resting potential; its gating is moderately affected by membrane potential and is not dependent on the activity of intracellular calcium ions. Application of serotonin to the cell body or intracellular injection of cyclic AMP causes prolonged and complete closure of the channel, thereby reducing the effective number of active channels in the membrane. The closure of the channel can account for the increases in the duration of the action potential, Ca2+ influx, and transmitter release which underlie behavioural sensitization, a simple form of learning.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Hamill, O., Marty, A., Neher, E., Sakmann, B. & Sigworth, F. J. Pflügers Arch. ges. Physiol. 391, 85–100 (1981).
Conti, F. & Neher, E. Nature 287, 140–143 (1980).
Sigworth, F. J. & Neher, E. Nature 291, 426–428 (1980).
Horn, R., Patlak, J. & Stevens, C. Nature 291, 426–428 (1981).
Lux, H. D. & Nagy, K. Pflügers Arch. ges. Physiol. 391, 252–254 (1981).
Marty, A. Nature 291, 497–500 (1981).
Pallotta, B. S., Magleby, K. K. & Barret, J. J. Nature 293, 471–474 (1981).
Colquhoun, C., Neher, E., Reuter, H. & Stevens, C. F. Nature 294, 752–754 (1981).
Yellen, G. Nature 396, 357–359 (1982).
Neher, E. & Sakmann, B. Nature 260, 799–802 (1976).
Patlak, J. B., Oration, K. A. F. & Usherwood, P. N. R. Nature 278, 643–645 (1979).
Miledi, R., Parker, I. & Cull-Candy, S. J. Physiol., Lond. 321, 195–210 (1981).
Colquhoun, D. & Sakmann, B. Nature 294, 464–466 (1981).
Tsien, R. W. & Siegelbaum, S. in Physiological Basis of Membrane Disorders (Plenum, New York, 1978).
Kehoe, J. & Marty, A. A. Rev. Biophys. Bioengng 9, 437–465 (1980).
Hartzel, H. C. Nature 291, 539–544 (1981).
Klein, M., Shapiro, E. & Kandel, E. R. J. exp. Biol. 89, 117–157 (1980).
Greengard, P. Harvey Lect. 75 (1981).
Gershenfeld, H. M., Paupardin-Tritsch, D. & Deterre, P. in Serotonin Neurotransmission and Behavior (MIT Press, 1981).
Pellmar, T. C. & Carpenter, D. O. Nature 277, 483–484 (1977).
Klein, M. & Kandel, E. R. Proc. natn. Acad. Sci. U.S.A. 75, 3512–3516 (1978).
Brunelli, M., Castellucci, V. & Kandel, E. R. Science 194, 1178–1181 (1976).
Castellucci, V. F. et al. Proc. natn. Acad. Sci. U.S.A. 77, 7492–7496 (1980).
Klein, M. & Kandel, E. R. Proc. natn. Acad. Sci. U.S.A. 77, 6912–6916 (1980).
Camardo, J., Klein, M. & Kandel, E. R. Soc. Neurosci. Abstr. 7, 836 (1981).
Adams, D. J., Smith, S. J. & Thompson, S. H. A. Rev. Neurosci. 3, 141–163 (1980).
Brown, D. A. & Adams, R. P. Nature 283, 672–676 (1980).
Anderson, C. R. & Stevens, C. F. J. Physiol., Lond., 235, 665–692 (1973).
Hodgkin, A. L. & Katz, B. J. Physiol., Lond. 108, 37–77 (1949).
Hamill, O. & Sakmann, B. Nature 294, 462–464 (1981).
Klein, M., Camardo, J. S. & Kandel, E. R. Proc. natn. Acad. Sci. U.S.A. 79 (in the press).
Reuter, H., Stevens, C. F., Tsein, R. W. & Yellen, G. Nature 297, 501–504 (1982).
Paupardin-Tritsch, D., Deterre, P. & Gershenfeld, H.M. Brain Res. 217, 201–206 (1981).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Siegelbaum, S., Camardo, J. & Kandel, E. Serotonin and cyclic AMP close single K+ channels in Aplysia sensory neurones. Nature 299, 413–417 (1982). https://doi.org/10.1038/299413a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/299413a0
This article is cited by
-
Neuropeptide Neuromedin B does not alter body weight and glucose homeostasis nor does it act as an insulin-releasing peptide
Scientific Reports (2022)
-
Memory formation depends on both synapse-specific modifications of synaptic strength and cell-specific increases in excitability
Nature Neuroscience (2018)
-
Protein kinase C acts as a molecular detector of firing patterns to mediate sensory gating in Aplysia
Nature Neuroscience (2012)
-
State-Dependent Disruption of Short-Term Facilitation Due to Overexpression of the apPDE4 Supershort Form in Aplysia
Molecules and Cells (2011)
-
Endogenous Serotonin Excites Striatal Cholinergic Interneurons via the Activation of 5-HT 2C, 5-HT6, and 5-HT7 Serotonin Receptors: Implications for Extrapyramidal Side Effects of Serotonin Reuptake Inhibitors
Neuropsychopharmacology (2007)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
