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Effect of somatic mutation within translocated c-myc genes in Burkitt's lymphoma

Nature volume 309, pages 592–597 (1984)Cite this article

Abstract

Our previous studies of a translocated c-myc gene in the Raji Burkitt's lymphoma cell showed somatic mutations in exons 1 and 2. We have extended these observations to two other translocated c-myc genes and find a common occurrence of mutation in the noncoding exon 1. We also found that in Raji cells, unlike other Burkitt's lymphoma cell lines, the normal allele of the c-myc gene is transcribed as well as the translocated gene. These results support a model in which c-myc oncogene activation in Burkitt's lymphoma occurs by disruption of a normal transcriptional control mechanism in which the c-myc protein is itself involved.

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Author notes

  1. R. Baer

    Present address: Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York, 10021, USA

Authors and Affiliations

  1. MRC Laboratory of Molecular Biology, MRC Centre, Hills Road, Cambridge, CB2 2QH, UK

    T. H. Rabbitts, A. Forster & R. Baer

  2. Ludwig Institute for Cancer Research, MRC Centre, Hills Road, Cambridge, CB2 2QH, UK

    P. Hamlyn

Authors
  1. T. H. Rabbitts
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  2. A. Forster
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  3. P. Hamlyn
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  4. R. Baer
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Rabbitts, T., Forster, A., Hamlyn, P. et al. Effect of somatic mutation within translocated c-myc genes in Burkitt's lymphoma. Nature 309, 592–597 (1984). https://doi.org/10.1038/309592a0

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