Abstract
Our previous studies of a translocated c-myc gene in the Raji Burkitt's lymphoma cell showed somatic mutations in exons 1 and 2. We have extended these observations to two other translocated c-myc genes and find a common occurrence of mutation in the noncoding exon 1. We also found that in Raji cells, unlike other Burkitt's lymphoma cell lines, the normal allele of the c-myc gene is transcribed as well as the translocated gene. These results support a model in which c-myc oncogene activation in Burkitt's lymphoma occurs by disruption of a normal transcriptional control mechanism in which the c-myc protein is itself involved.
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Rabbitts, T., Forster, A., Hamlyn, P. et al. Effect of somatic mutation within translocated c-myc genes in Burkitt's lymphoma. Nature 309, 592–597 (1984). https://doi.org/10.1038/309592a0
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DOI: https://doi.org/10.1038/309592a0
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