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Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

Abstract

Transcription of the c-fos proto-oncogene is greatly increased within minutes of administering purified growth factors to quiescent 3T3 cells. This stimulation is the most rapid transcriptional response to peptide growth factors yet described, and implies a role for c-fos in cell-cycle control Transformation by c-fos may result from a temporal deregulation of this control.

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Greenberg, M., Ziff, E. Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature 311, 433–438 (1984). https://doi.org/10.1038/311433a0

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