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Regulation of a protein synthesis initiation factor by adenovirus virus-associated RNAI

Nature volume 313, pages 196–200 (1985)Cite this article

Abstract

A small RNA accumulating late in adenovirus infection is required for efficient protein synthesis, although not specifically for the translation of viral proteins. This RNA maintains the activity of an initiation factor catalysing the earliest step of polypeptide chain initiation.

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References

  1. Reich, P. R., Rose, J., Forget, B. & Weissman, S. M. J. molec. Biol. 17, 428–439 (1966).

    Article  CAS  Google Scholar 

  2. Pettersson, U. & Philipson, L. Cell 6, 1–4 (1975).

    Article  CAS  Google Scholar 

  3. Mathews, M. B. Cell 6, 223–229 (1975).

    Article  CAS  Google Scholar 

  4. Mathews, M. B. & Pettersson, U. J. molec. Biol. 119, 293–328 (1978).

    Article  CAS  Google Scholar 

  5. Akusjärvi, G., Mathews, M. B., Andersson, P., Vennström, B. & Pettersson, U. Proc. natn. Acad. Sci. U.S.A. 77, 2424–2428 (1980).

    Article  ADS  Google Scholar 

  6. Sölund, H., Vennström, B., Philipson, L. & Mathews, M. B. Cell 7, 585–593 (1976).

    Article  Google Scholar 

  7. Zain, S., Gingeras, T. R., Bullock, P., Wong, G. & Gelinas, R. E. J. molec. Biol. 135, 413–433 (1979).

    Article  CAS  Google Scholar 

  8. Monstein, J.-H. & Philipson, L. Nucleic Acids Res. 9, 4239–4250 (1981).

    Article  CAS  Google Scholar 

  9. Mathews, M. B. Nature 285, 575–577 (1980).

    Article  ADS  CAS  Google Scholar 

  10. Lerner, M. R., Boyle, J. A., Hardin, J. A. & Steitz, J. A. Science 211, 400–402 (1981).

    Article  ADS  CAS  Google Scholar 

  11. Francoeur, A. M. & Mathews, M. B. Proc. natn. Acad. Sci. U.S.A. 79, 6772–6776 (1982).

    Article  ADS  CAS  Google Scholar 

  12. Stefano, J. E. Cell 36, 145–154 (1984).

    Article  CAS  Google Scholar 

  13. Mathews, M. B. & Francoeur, M. Molec. cell Biol. 4, 1134–1140 (1984).

    Article  CAS  Google Scholar 

  14. Price, R. & Penman, S. J. molec. Biol. 70, 435–450 (1972).

    Article  CAS  Google Scholar 

  15. Weinmann, R., Brendler, T. G., Raskas, H. J. & Roeder, R. G. Cell 7, 557–566 (1976).

    Article  CAS  Google Scholar 

  16. Thimmappaya, B., Weinberger, C., Schneider, R. J. & Shenk, T. Cell 31, 543–551 (1982).

    Article  CAS  Google Scholar 

  17. Svensson, C. & Akusjärvi, G. Molec. cell Biol. 4, 736–742 (1984).

    Article  CAS  Google Scholar 

  18. Schneider, R. J., Weinberger, C. & Shenk, T. Cell 37, 291–298 (1984).

    Article  CAS  Google Scholar 

  19. Towbin, H., Staehelin, T. & Gordon, J. Proc. natn. Acad. Sci. U.S.A. 76, 4350–4354 (1979).

    Article  ADS  CAS  Google Scholar 

  20. Babich, A., Feldman, L. T., Nevins, J. R., Darnell, J. E. Jr & Weinberger, C. Molec. Cell Biol. 3, 1212–1221 (1983).

    Article  CAS  Google Scholar 

  21. Babiss, L. E. & Ginsberg, H. S. J. Virol. 50, 202–212 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  22. Jagus, R., Anderson, W. F. & Safer, B. Prog. Nucleic Acid Res. molec. Biol. 25, 127–185 (1981).

    Article  CAS  Google Scholar 

  23. Jackson, R. J. in Protein Biosynthesis in Eukaryotes (ed. Perez-Bercoff, R.) 363–408 (Plenum, New York, 1980).

    Google Scholar 

  24. Safer, B. Cell 33, 7–8 (1983).

    Article  CAS  Google Scholar 

  25. Ochoa, S. Archs Biochem. Biophys. 223, 325–349 (1983).

    Article  CAS  Google Scholar 

  26. Clemens, M. J., Pain, V. M., Wong, S.-T. & Henshaw, E. C., Nature 296, 93–95 (1982).

    Article  ADS  CAS  Google Scholar 

  27. Panniers, R. & Henshaw, E. C. J. biol. Chem. 258, 7928–7934 (1983).

    CAS  PubMed  Google Scholar 

  28. Siekierka, J., Mauser, L. & Ochoa, S., Proc. natn. Acad. Sci. U.S.A. 79, 2537–2540 (1982).

    Article  ADS  CAS  Google Scholar 

  29. Mathews, M. B., Hunt, T. & Brayley, A. Nature new Biol. 243, 230–233 (1973).

    Article  CAS  Google Scholar 

  30. Walter, P. & Blobel, G. Nature 299, 691–698 (1982).

    Article  ADS  CAS  Google Scholar 

  31. Merrick, W. C. Meth. Enzym. 60, 101–108 (1979).

    Article  CAS  Google Scholar 

  32. Laemmli, U. K. Nature 227, 680–685 (1970).

    Article  ADS  CAS  Google Scholar 

  33. Bonner, W. M. & Laskey, R. A. Eur. J. Biochem. 46, 83–88 (1974).

    Article  CAS  Google Scholar 

  34. Pelham, H. R. B. & Jackson, R. J. Eur. J. Biochem. 67, 247–256 (1976).

    Article  CAS  Google Scholar 

  35. Pettersson, U. & Mathews, M. B. Cell 12, 741–750 (1977).

    Article  CAS  Google Scholar 

  36. Ricciardi, R., Miller, J. S. & Roberts, B. E., Proc. natn. Acad. Sci. U.S.A. 76, 4927–4931 (1979).

    Article  ADS  CAS  Google Scholar 

  37. Stillman, B. W., Lewis, J. B., Chow, L. T., Mathews, M. B. & Smart, J. E. Cell 23, 497–508 (1981).

    Article  CAS  Google Scholar 

  38. Siekierka, J., Mitsui, K.-I. & Ochoa, S., Proc. natn. Acad. Sci. U.S.A. 78, 220–223 (1981).

    Article  ADS  CAS  Google Scholar 

  39. Siekierka, J., Mariano, T. M., Reichel, P. A. & Mathews, M. B., Proc. natn. Acad. Sci. U.S.A. (in the press).

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Author notes

  1. William C. Merrick: Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA

  2. John Siekierka: Department of Biochemistry, The Roche Institute of Molecular Biology, Nutley, New Jersey 07110, USA

Authors and Affiliations

  1. Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, New York, 11724, USA

    Patricia A. Reichel, William C. Merrick, John Siekierka & Michael B. Mathews

Authors
  1. Patricia A. Reichel
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  2. William C. Merrick
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  3. John Siekierka
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  4. Michael B. Mathews
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Reichel, P., Merrick, W., Siekierka, J. et al. Regulation of a protein synthesis initiation factor by adenovirus virus-associated RNAI. Nature 313, 196–200 (1985). https://doi.org/10.1038/313196a0

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