Abstract
It is generally accepted that tumours arise through the accumulation of several changes affecting the control of cell growth. Recent advances in molecular biology have made it possible to define some of these changes in molecular terms and to trace the steps by which certain tumours evolve.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Farber, E. & Cameron, R. Adv. Cancer Res. 31, 125–226 (1980).
Knudson, A. Adv. Cancer Res. 17, 317 (1973).
Foulds, L. Cancer Res. 14, 327–339 (1954).
Foulds, L. J. Chron. Dis. 8, 2–37 (1958).
Nowell, P. C. Science 194, 23–28 (1976).
Temin, H. J. Cell Physiol. Suppl. 3, 1–11 (1984).
Rous, P. & Beard, J. W. J. exp. Med. 69, 399–424 (1939).
Klein, G. (ed.) Advances in Viral Oncology Vol. 1 (Raven, New York, 1982).
Barbacid, M. 3rd Duran Reynals Int. Symp., Barcelona (in the press).
Cavenee, W. K. et al. Nature 305, 779–784 (1983).
Murphree, A. L. & Benedict, W. F. Science 223, 1028–1033 (1984).
Benedict, W. F. et al. Science 219, 973–975 (1983).
Knudson, A. G. Proc. natn. Acad. Sci. U.S.A. 68, 820–823 (1971).
Knudson, A. G. & Strong, L. C. Am. J. hum. Genet. 24, 514 (1972).
Comings, E. E. Proc. natn. Acad. Sci. U.S.A. 70, 3324–3328 (1973).
Robertson, M. Nature 309, 512–513 (1984).
Harris, H. et al. Nature 223, 363–368 (1969).
Klein, G. et al. J. Cell. Sci. 8, 659–672 (1981).
Wiener, F. et al. J. Cell. Sci. 12, 253–261 (1973).
Stanbridge, E. J. Nature 260, 17–20 (1976).
Jonasson, J. et al. J. Cell Sci. 24, 217 (1977).
Spira, J. et al. Int. J. Cancer 28, 785–798 (1981).
Evans, E. P. et al. J. Cell Sci. 56, 113–130 (1982).
Klinger, H. P. & Shows, T. B. J. natn. Cancer Inst. 71, 559–569 (1983).
Noda, M. et al. Proc. natn. Acad. Sci. U.S.A. 80, 5602–5606 (1983).
Taniguchi, K., Kärre, K. & Klein, G. Int. J. Cancer (in the press).
De-Baetselier, P. et al. Nature 288, 199 (1980).
Katzav, S. et al. J. natn. Cancer Inst. 71, 317 (1983).
Sandersson, A. R. & Beverley, P. E. Immun. Today 4, 2111 (1983).
Nicolson, G. L. Biochim. biophys. Acta 695, 113–176 (1982).
Danö, K. et al. Adv. Cancer Res. 44, 140–239 (1985).
Dalianis, T. et al. Immunogenetics 9, 465–475 (1979).
Fenyö, E. M. & Klein, G. Nature 260, 355–357 (1976).
Geser, A. et al. Int. J. Cancer 29, 297–400 (1982).
Klein, G. Cold Spring Harb. Symp. quant. Biol. 39, 783–790 (1975).
Klein, G. & Klein, E. Carcinogen 5, 429–435 (1984).
Klein, G. Cell 32, 311–315 (1983).
Murray, M. J. et al. Cell 33, 749–757 (1983).
Diamond, A. Nature 305, 112–116 (1983).
Kieff, E. et al. Adv. Viral Oncol. 3, 133–182 (1983).
Menezes, J. et al. Expl Cell Res. 92, 478–484 (1975).
Rymo, L. & Klein, G. Proc. natn. Acad. Sci. U.S.A. (in the press).
Dillner, J., Kallin, B. et al. Int. J. Cancer 35, 359–366 (1985).
Hennessy, K. & Kieff, E. Proc. natn. Acad. Sci. U.S.A. 80, 5665–5669 (1983).
Summers, W. et al. Proc. natn. Acad. Sci. U.S.A. 79, 5688–5692. (1982).
Klein, G. & Klein, E. Prog. Med. Virol. 30, 87–106 (1984).
Gordon, J. et al. Nature 310, 145–147 (1984).
Sporn, M. & Roberts, A. B. Nature 313, 745–747 (1985).
Gordon, J. et al. Int. J. Cancer 35, 251–256 (1985).
Furth, J. Cancer Res. 13, 477–492 (1953).
Leder, P. et al. Science 222, 765–771 (1983).
Shen-Ong, G-L. et al. Cell 31, 443–452 (1982).
Adams, J. M. et al. Proc. natn. Acad. Sci. U.S.A. 79, 6966–6970 (1982).
Adams, J. M. et al. Proc. natn. Acad. Sci. U.S.A. 80, 1982–1986 (1983).
Cory, S. et al. EMBO J. 2, 213–216 (1983).
Cory, S. et al. Science 219, 963–967 (1983).
Dalla-Favera, R. et al. Science 219, 963–967 (1983).
Erikson, J. et al. Proc. natn. Acad. Sci. U.S.A. 80, 820–824 (1983).
Taub, R. et al. Proc. natn. Acad. Sci. U.S.A. 79, 7837–7841 (1982).
Calame, K. et al. Proc. natn. Acad. Sci. U.S.A. 79, 6994–6998 (1982).
Harris, L. J. et al. Proc. natn. Acad. Sci. U.S.A. 79, 4175–4179 (1982).
Stanton, L. W. et al. Nature 303, 401–406 (1983).
Perry, R. P. Cell 33, 647–649 (1983).
Croce, C. M. et al. Proc. natn. Acad. Sci. U.S.A. 80, 6922–6926 (1983).
Erikson, J. et al. Proc. natn. Acad. Sci. U.S.A. 80, 7581–7585 (1983).
Emanuel, B. S. et al. Proc. natn. Acad. Sci. U.S.A. 81, 2444–2446 (1984).
Weisbrod, S. Nature 297, 289–295 (1982).
Rabbitts, T. H. et al. Nature 309, 592–597 (1984).
Robertson, M. Nature 309, 585–587 (1984).
Kelly, K. et al. Cell 35, 603–610 (1983).
Campisi, J. et al. Cell 36, 241–247 (1984).
Reitsma, P. H. et al. Nature 306, 492–494 (1983).
Croce, C. M. & Klein, G. Scient. Am. 252(3), 54–60 (1985).
Adams, J. M. et al. Proc. natn. Acad. Sci. U.S.A. 80, 1982–1986 (1983).
Erikson, J. et al. Proc. natn. Acad. Sci. U.S.A. 80, 820–824 (1983).
Harris, L. J. et al. Proc. natn. Acad. Sci. U.S.A. 79, 4175–4179 (1982).
Stanton, L. W. et al. Nature 303, 401–406 (1983).
Leder, P. et al. Science 222, 765–771 (1983).
Guerrero, I. 3rd Duran Reynals Int. Symp., Barcelona (in the press).
Klein, G. Proc. natn. Acad. Sci. U.S.A. 76, 2442–2446 (1979).
Burkitt, D. P. J. natn. Cancer Inst. 42, 19–28 (1969).
Klein, G. Nature 294, 313–318 (1981).
Nilsson, K. & Klein, G. Adv. Cancer Res. 37, 319–380 (1982).
Potter, M. et al. Adv. Viral Oncol. 4, 139–162 (1984).
Perlmutter, R. M. et al. Nature 307, 473–476 (1984).
Rechavi, G. et al. Nature 300, 607–611 (1982).
Canaani, E. et al. Proc. natn. Acad. Sci. U.S.A. 80, 7118–7122 (1983).
Klein, G. in Genetic Rearrangements in Leukaemia and Lymphoma (eds Goldman. J M & Harnden, D. G.) (Churchill Livingstone, London, in the press).
Ohno, S. et al. J. exp. Med. 159, 1762–1777 (1984).
Mushinski, J. F. et al. Science 220, 795–798 (1983).
Shen-Ong, G. L. C. et al. Curr. Top. Microbiol. Immun. 113, 41–46 (1984).
Lavu, S. et al. Curr. Top. Microbiol. Immun. 113, 37–40 (1984).
Rowley, J. Cancer Genet. Cytogenet. 1, 263–271 (1981).
Tsujimoto, Y. et al. Science 224, 1403–1406 (1984).
Little, C. D. et al. Nature 306, 194–196 (1983).
Whang-Peng, J. et al. Science 215, 181–182 (1982).
Cohen, A. J. New Engl. J. Med. 301, 592–595 (1979).
Pathak, S. et al. Science 217, 939–941 (1982).
Bonner, T. et al. Science 223, 71–74 (1984).
Santos, E. et al. Science 223, 661–664 (1984).
Nakano, H. et al. Proc. natn. Acad. Sci. U.S.A. 81, 71–75 (1984).
Capon, J. J. et al. Nature 304, 507–510 (1982).
Collins, S. & Groudine, M. Nature 298, 679–681 (1982).
Alitalo, K. et al. Proc. natn. Acad. Sci. U.S.A. 80, 1707–1711 (1983).
Hayashi, K. et al. Gann 75, 475–478 (1984).
Brodeur, G. M. et al. Science 224, 1121–1124 (1984).
Sümegi, J. et al. (in preparation).
Schwab, M. et al. Nature (in the press).
Levan, G. et al. Hereditas 86, 75–90 (1977).
Hayward, W. S. et al. Nature 290, 475–480 (1981).
Keath, E. J. et al. Cell 39, 339–348 (1984).
Makino, S. Ann N. Y. Acad. Sci. 64, 818–822 (1956).
Levan, A. & Biesele, J. Ann. N. Y. Acad. Sci. 72, 1022–1026 (1968).
Hauschka, T. S. Cancer Res. 21, 957–961 (1961).
Rowley, J. Proc. natn. Acad. Sci. U.S.A. 72, 152–155 (1975).
Levan, G. & Mitelman, F. Hereditas 84, 1–14 (1976).
Jacobsen, R. J. et al. New Engl. J. Med. 310, 1513–1517 (1984).
Heisterkamp, N. et al. Nature 299, 747–750 (1982).
DeKlein, A. et al. Nature 300, 765–767 (1982).
Bertram, C. R. et al. Nature 306, 277–280 (1983).
Heisterkamp, N. et al. Nature 306, 239–242 (1983).
Groffen, J. et al. Cell 36, 93–99 (1984).
Canaani, E. et al. Lancet i, 593–595 (1984).
De Grouchy, J. & Turleau, C. in Chromosomes and Cancer (ed. German, J.) 287–298 (Wiley, New York, 1974).
Levan, G. & Mitelman, F. Hereditas 79, 156 (1970).
Wiener, F. et al. J. natn. Cancer Inst. 61, 227–238 (1978).
Wiener, F. et al. Int. J. Cancer 22, 447–453 (1978).
Klein, G. Nature 294, 313–318 (1981).
Sümegi, J. et al. Nature 306, 497–498 (1983).
Cory, S. et al. EMBO J. 2, 697–703 (1983).
Klein, G. & Klein, E. Proc. natn. Acad. Sci. U.S.A. 74, 2121–2126 (1977).
Purtilo, D. T. & Klein, G. Cancer Res. 41, 4209 (1981).
Saemundsen, A. K. et al. Cancer Res. 41, 4237–4242 (1981).
Masucci, N. G. et al. Cancer Res. 41, 4284–4291 (1981).
Hanto, D. W. et al. Cancer Res. 41, 4253–4261 (1981).
Saemundsen, A. K. et al. Lancet ii, 158 (1982).
Ziegler, J. Adv. Viral Oncol. 5, 239–255 (1985).
Rickinson, A. B. & Moss, D. T. Adv. Viral Oncol. 3, 213–238 (1983).
Szigeti, R. et al. Proc. natn. Acad. Sci. U.S.A. 81, 4178–4182 (1984).
Penn, I. Adv. Cancer Res. 28, 32–61 (1978).
Beth, E. & Girado, G. Int. J. Cancer 26, 23–29 (1980).
zur Hausen, H. 3rd Duran Reynals Int. Symp., Barcelona (in the press).
Hanna, N. & Burton, R. C. J. Immun. 127, 1753–1758 (1981).
Gorelik, E. & Bere, W. W. Int. J. Cancer 33, 87–94 (1984).
Dalianis, T. et al. Immunogenetics 12, 371–380 (1981).
Blair, D. G. et al. in Cancer Cells (ed. van de Woude, G. F.) 281–289 (Cold Spring Harbor Laboratory, New York, 1984).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Klein, G., Klein, E. Evolution of tumours and the impact of molecular oncology. Nature 315, 190–195 (1985). https://doi.org/10.1038/315190a0
Published:
Issue Date:
DOI: https://doi.org/10.1038/315190a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.