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Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells

Abstract

The partial amino-acid sequence of purified human transforming growth factor-β (TGF-β) was used to identify a series of cDNA clones encoding the protein. The cDNA sequence indicates that the 112-amino acid monomeric form of the natural TGF-β homodimer is derived proteolytically from a much longer precursor polypeptide which may be secreted. TGF-β messenger RNA is synthesized in various normal and transformed cells.

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Derynck, R., Jarrett, J., Chen, E. et al. Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells. Nature 316, 701–705 (1985). https://doi.org/10.1038/316701a0

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