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Reshaping human antibodies for therapy

Nature volume 332, pages 323–327 (1988)Cite this article

Abstract

A human IgGI antibody has been reshaped for serotherapy in humans by introducing the six hypervariable regions from the heavy- and light-chain variable domains of a rat antibody directed against human lymphocytes. The reshaped human antibody is as effective as the rat antibody in complement and is more effective in cell-mediated lysis of human lymphocytes.

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Author notes

  1. Michael Clark and Herman Waldmann: Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK

  2. Lutz Riechmann: Address from April 1988: Department of Molecular Biology, The Research Institute of Scripps Clinic, North Torrey Pines Road, La Jolla, California 02937, USA

  3. Greg Winter: To whom correspondence should be addressed.

Authors and Affiliations

  1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK

    Lutz Riechmann, Michael Clark, Herman Waldmann & Greg Winter

Authors
  1. Lutz Riechmann
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  2. Michael Clark
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  3. Herman Waldmann
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  4. Greg Winter
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Riechmann, L., Clark, M., Waldmann, H. et al. Reshaping human antibodies for therapy. Nature 332, 323–327 (1988). https://doi.org/10.1038/332323a0

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