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Sequences homologous to ZFY, a candidate human sex-determining gene, are autosomal in marsupials

Nature volume 336, pages 780–783 (1988)Cite this article

Abstract

Sexual differentiation in placental mammals results from the action of a testis-determining gene encoded by the Y chromosome. This gene causes the indifferent gonad to develop as a testis, thereby initiating a hormonal cascade which produces a male phenotype1,2. Recently, a candidate for the testis-determining gene (ZFY, Y-borne zinc-finger protein) has been cloned3,4. The ZFY probe detects a male-specific (Y-linked) sequence in DNA from a range of eutherian mammals, as well as an X-linked sequence (ZFX) which maps to the human X chromosome3. In marsupials it is also the Y chromosome that seems to determine the fate of the gonad, but not all sexual dimorphisms5. Using the ZFY probe we find, surprisingly, that the ZFY homologous sequences are not on either the X or the Y chromosome in marsupials, but map to the auto-somes. This implies ZFY is not the primary sex-determining gene in marsupials. Either the genetic pathways of sex determination in marsupials and eutherians differ, or they are identical and ZFY is not the primary signal in human sex determination.

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References

  1. Ohno, S. Sex Chromosomes and Sex-linked Genes (Springer, Berlin, 1967).

    Book  Google Scholar 

  2. Jost, A., Vigier, B., Prepin, J. & Perchellet, J. P. Recent Prog. Horm. Res. 29, 1–35 (1973).

    CAS  PubMed  Google Scholar 

  3. Page, D. C. et al. Cell 51, 1091–1104 (1987).

    Article  CAS  Google Scholar 

  4. Page, D. C. Phil. Trans. R. Soc. B (in the press).

  5. Sharman, G. B., Robinson, E. S., Walton, S. M. & Berger, P. J. J. reprod. Fert. 21, 57–68 (1970).

    Article  CAS  Google Scholar 

  6. Air, G. M., Thompson, E. O. P., Richardson, B. J. & Sharman, G. B. Nature 229, 391–394 (1971).

    Article  ADS  CAS  Google Scholar 

  7. Archer, M. Vertebrate Zoogeography and Evolution in Australasia (eds Archer, M. & Clayton, G.) 780–781 (Hesperian, Western Australia, 1984).

    Google Scholar 

  8. Graves, J. A. M. Genetic Maps 4 (ed. O'Brien, S. J.) 504–507 (Cold Spring Harbor, New York, 1987).

    Google Scholar 

  9. Dawson, G. W. & Graves, J. A. M. Cytogenet. Cell Genet. 42, 80–84 (1986).

    Article  Google Scholar 

  10. Sinclair, A. H. thesis, La Trobe Univ., Australia (1988).

  11. Graves, J. A. M., Sinclair, A. H. & Spencer, J. A. Aust. J. Zool. (in the press).

  12. Sinclair, A. H., Wrigley, J. M. & Graves, J. A. M. Genet. Res. 50, 131–136 (1987).

    Article  CAS  Google Scholar 

  13. Davies, K. E., Mandel, J. L., Weissenbach, J. & Fellous, M. Cytogenet. Cell Genet. 46, 277–315 (1987).

    Article  CAS  Google Scholar 

  14. Hayman, D. L., Ashworth, L. K. & Carrano, A. V. Cell Genet. 34, 365–370 (1982).

    Article  Google Scholar 

  15. Sharp, P. Chromosoma 86, 27–47 (1982).

    Article  CAS  Google Scholar 

  16. Graves, J. A. M. Trends Genet. 3, 252–256 (1987).

    Article  Google Scholar 

  17. Scott, D. J. & Sinclair, A. H. Biometrics (in the press).

  18. O, W.-S., Short, R. V., Renfree, M. B. & Shaw, G. Nature 331, 716–717 (1988).

    Article  ADS  CAS  Google Scholar 

  19. Renfree, M. B. & Short, R. V. Phil. Trans. R. Soc. B (in the press).

  20. Wilson, J. D., George, F. W. & Griffin, J. E. Science 211, 1278–1284 (1981).

    Article  ADS  CAS  Google Scholar 

  21. Kratochwil, K. Devl Biol. 61, 358–365 (1977).

    Article  CAS  Google Scholar 

  22. Southern, E. J. J. molec. Biol. 98, 503–517 (1975).

    Article  CAS  Google Scholar 

  23. Reed, K. C. & Mann, D. Nucleic Acids Res. 13, 7207–7221 (1985).

    Article  CAS  Google Scholar 

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Author notes

  1. Andrew H. Sinclair

    Present address: Human Molecular Genetics Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, WC2A 3PX, UK

  2. David C. Page: Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA

  3. Mark Palmer and Peter N. Goodfellow: Human Molecular Genetics Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX, UK

Authors and Affiliations

  1. Department of Genetics and Human Variation, La Trobe University, Bundoora, Victoria, 3083, Australia

    Andrew H. Sinclair, Jamie W. Foster, James A. Spencer, David C. Page, Mark Palmer, Peter N. Goodfellow & Jennifer A. Marshall Graves

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  1. Andrew H. Sinclair
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  2. Jamie W. Foster
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  7. Jennifer A. Marshall Graves
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Sinclair, A., Foster, J., Spencer, J. et al. Sequences homologous to ZFY, a candidate human sex-determining gene, are autosomal in marsupials. Nature 336, 780–783 (1988). https://doi.org/10.1038/336780a0

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