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A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

Nature volume 337, pages 331–337 (1989)Cite this article

Abstract

The telomerase enzyme of Tetrahymena synthesizes repeats of the telomeric DNA sequence TTGGGG de novo in the absence of added template. The essential RNA component of this ribonucleoprotein enzyme has now been cloned and found to contain the sequence CAACCCCAA, which seems to be the template for the synthesis of TTGGGG repeats.

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Authors and Affiliations

  1. Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, New York, 11724, USA

    Carol W. Greider

  2. Department of Molecular Biology, University of California, Berkeley, California, 94720, USA

    Elizabeth H. Blackburn

Authors
  1. Carol W. Greider
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  2. Elizabeth H. Blackburn
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Greider, C., Blackburn, E. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 337, 331–337 (1989). https://doi.org/10.1038/337331a0

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