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Structure of tumour necrosis factor

Nature volume 338, pages 225–228 (1989)Cite this article

Abstract

Tumour necrosis factor is a trimeric molecule, each subunit of which consists of an antiparallel β sandwich. Individual subunits form the trimer by a novel edge-to-face packing of β sheets. A comparison of the subunit fold with that of other proteins reveals a remarkable similarity to the 'jelly-roll' structural motif characteristic of viral coat proteins.

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References

  1. Old, L. J. Nature 326, 330–331 (1987).

    Article  ADS  CAS  Google Scholar 

  2. Carswell, E. A. et al. Proc. natn. Acad. Sci. U.S.A. 72, 3666–3670 (1975).

    Article  ADS  CAS  Google Scholar 

  3. Gifford, G. E. & Flick, D. A. in ‘Tumour Necrosis Factor and Related Cytotoxins’ (Ciba Foundation Symposium 131) 3–20 (Wiley, Chichester, 1987).

    Google Scholar 

  4. Beutler, B. & Cerami, A. A. Rev. Biochem. 57, 505–518 (1988).

    Article  CAS  Google Scholar 

  5. Mestan, J. et al. Nature 323, 816–819 (1986).

    Article  ADS  CAS  Google Scholar 

  6. Wong, G. H. W. & Goeddel, D. V. Nature 323, 819–822 (1986).

    Article  ADS  CAS  Google Scholar 

  7. Playfair, J. H. L. & Taverne, J. in ‘Tumour Necrosis Factor and Related Cytotoxins’ (Ciba Foundation Symposium 131) 192–205 (Wiley, Chichester, 1987).

    Google Scholar 

  8. Wollheim, F. A., Heinegard, D., Palladino, M., Saxne, T. & Talal, N. Arthritis Rheum. 30, 129 (1987).

    Google Scholar 

  9. Saklatvala, J. Nature 322, 547–549 (1986).

    Article  ADS  CAS  Google Scholar 

  10. Cerami, A. & Beutler, B. Nature 320, 584–588 (1986).

    Article  ADS  Google Scholar 

  11. Smith, R. A. & Baglioni, C. J. biol. Chem. 262, 6951–6954 (1987).

    CAS  PubMed  Google Scholar 

  12. Scheurich, P., Ucer, U., Kronke, M. & Pfizenmaier, K. Int. J. Cancer 38, 127–133 (1986).

    Article  CAS  Google Scholar 

  13. Israel, S., Hahn, T., Holtmann, H. & Wallach, D. Immun. Lett. 12, 217–224 (1986).

    Article  CAS  Google Scholar 

  14. Creasey, A. A., Yamamoto, R. & Vitt, C. R. Proc. natn. Acad. Sci. U.S.A. 84, 3293–3297 (1987).

    Article  ADS  CAS  Google Scholar 

  15. Yoshie, O., Tada, K. & Ishida, N. J. Biochem. 100, 531–541 (1986).

    Article  CAS  Google Scholar 

  16. Vitt, C. R., Yamamoto, R. & Creasey, A. A. Fedn Proc. 46, 2117 (1987).

    Google Scholar 

  17. Smith, R. A., Kirstein, M., Fiers, W. & Baglioni, C. J. biol. Chem. 261, 14871–14874 (1986).

    CAS  PubMed  Google Scholar 

  18. Wang, B. C. Meth. Enzym. 115, 90–111 (1985).

    Article  CAS  Google Scholar 

  19. Bricogne, G. Acta Crystallogr. A32, 832–847 (1976).

    Article  ADS  CAS  Google Scholar 

  20. Brünger, A. T., Kuriyan, J. & Karplus, M. Science 235, 458–460 (1987).

    Article  ADS  Google Scholar 

  21. Stuart, D. I., Levine, M., Muirhead, H. & Stammers, D. K. J. molec. Biol. 134, 109–142 (1979).

    Article  CAS  Google Scholar 

  22. Acharya, R. et al. Nature 337, 709–716 (1989).

    Article  ADS  CAS  Google Scholar 

  23. Reeke, G. N., Becker, J. W. & Edelman, G. M. J. biol. Chem. 250, 1525–1547 (1975).

    CAS  PubMed  Google Scholar 

  24. Argos, P., Tsukihara, T. & Rossmann, M. G. J. molec. Evol. 15, 169–179 (1980).

    Article  ADS  CAS  Google Scholar 

  25. Wilson, I. A., Skehel, J. J. & Wiley, D. C. Nature 289, 366–373 (1981).

    Article  ADS  CAS  Google Scholar 

  26. Harrison, S. C., Olson, A. J., Schutt, C. E., Winkler, F. K. & Bricogne, G. Nature 276, 368–373 (1978).

    Article  ADS  CAS  Google Scholar 

  27. Roberts, M. M., White, J. L., Grütter, M. G. & Burnett, R. M. Science 232, 1148–1151 (1986).

    Article  ADS  CAS  Google Scholar 

  28. Liljas et al. J. molec. Biol. 159, 93–108 (1982).

    Article  CAS  Google Scholar 

  29. Rossmann, M. G. et al. J. molec. Biol. 165, 711–736 (1983).

    Article  CAS  Google Scholar 

  30. Rossmann, M. G. et al. Nature 317, 145–153 (1985).

    Article  ADS  CAS  Google Scholar 

  31. Brandhuber, B. J., Boone, T., Kenney, W. C. & McKay, D. B. Science 238, 1707–1709 (1987).

    Article  ADS  CAS  Google Scholar 

  32. Priestle, J. P., Schär, H.-P. & Grütter, M. G. EMBO J. 7, 339–343 (1988).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Molecular Biophysics, The Rex Richards Building, South Parks Road, Oxford, 0X1 3QU, UK

    E. Y. Jones & D. I. Stuart

  2. Hauptlaboratorium, BASF Aktiengesellschaft, Carl-Bosch-Str. 38, 6700, Ludwigshafen/Rh., FRG

    N. P. C. Walker

Authors
  1. E. Y. Jones
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  2. D. I. Stuart
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  3. N. P. C. Walker
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Jones, E., Stuart, D. & Walker, N. Structure of tumour necrosis factor. Nature 338, 225–228 (1989). https://doi.org/10.1038/338225a0

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