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T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

Abstract

Effective interaction between T cells and their targets requires that recognition of specific antigen be coordinated with increased cell-cell adhesion. We show that antigen-receptor cross-linking increases the strength of the adhesion mechan-ism between lymphocyte function-associated molecule-1 (LFA-1) and intercellular adhesion molecules (ICAMs), with intracellular signals trans-mitted from the T-cell antigen receptor to the LFA-1 adhesion molecule. The increase in avidity is rapid and transient providing a dynamic mechanism for antigen-specific regulation of lymphocyte adhesion and de-adhesion.

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Dustin, M., Springer, T. T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature 341, 619–624 (1989). https://doi.org/10.1038/341619a0

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