Abstract
In transgenic mice, mature peripheral B lymphocytes in lymphoid follicles, like immature B cells, are rendered tolerant by encounter with self-antigen, provided receptor occupancy by self-antigen exceeds a critical threshold. The tolerant state of the B cell is closely correlated with down-regulation of membrane IgM but not IgD antigen-receptors. Identical changes in antigen-receptor expression occur in a subset of follicular B cells in nontransgenic mice, suggesting that clonally silenced self-reactive cells are common in the peripheral B-cell repertoire.
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References
Kappler, J. W., Roehm, N. & Marrack, P. Cell 49, 273–280 (1987).
MacDonald, H. R. et al. Nature 332, 40–45 (1988).
Kisielow, P. et al. Nature 333, 742–746 (1988).
Sha, W. C. et al. Nature 336, 73–76 (1988).
Pullen, A. M., Marrack, P. & Kappler, J. W. Nature 335, 796–800 (1988).
Lederberg, J. Science 129, 1649–1653 (1959).
Smith, C. A. et al. Nature 337, 181–184 (1989).
Chien, Y-H. et al. Nature 309, 322–326 (1984).
Ikuta, K., Ogura, T., Shimizu, A. & Honjo, T. Proc. natn. Acad. Sci. U.S.A. 82, 7701–7705 (1985).
Fink, P. J. et al. Nature 321, 219–226 (1986).
Berek, C. & Milstein, C. Immunol. Rev. 105, 5–26 (1988).
French, D. L., Laskov, R. & Scharff, M. D. Science 244, 1152–1157 (1989).
Diamond, B. & Scharff, M. D. Proc. natn. Acad. Sci. U.S.A. 81, 5841–5844 (1984).
Shlomchik, M. J., Aucoin, A. H., Pisetsky, D. S. & Weigert, M. G. Proc. natn. Acad. Sci. U.S.A. 84, 9150–9154 (1987).
Benjamin, D. C. et al. A. Rev. Immun. 2, 67–101 (1984).
Goodnow, C. C. & Basten, A. Sem. Immun. (in the press).
Lanzavecchia, A. Nature 314, 537–539 (1985).
Chiller, J. M., Habicht, G. S. & Weigle, W. O. Science 171, 813–815 (1971).
Katz, D. H., Hamaoka, T. & Benacerraf, B. J. exp. Med. 136, 1404–1429 (1972).
Weigle, W. O. Adv. Immun. 16, 61–122 (1973).
Howard, J. G. & Mitchison, N. A. Progr. Allergy. 18, 43–96 (1975).
Desaymard, C. & Waldmann, H. Nature 264, 780–782 (1976).
Metcalf, E. S., Schrater, A. F. & Klinman, N. R. Immunol. Rev. 43, 143–183 (1979).
Scott, D. W., Venkataraman, M. & Jandinski, J. J. Immunol. Rev. 43, 241–280 (1979).
Parks, D. E., Nelson, P. A., Walker, S. M. & Weigle, W. O. Ann. N.Y. Acad. Sci. 392, 210–222 (1982).
Nossal, G. J. V. A. Rev. Immun. 1, 33–62 (1983).
Goodnow, C. C. et al. Nature 334, 676–682 (1988).
Palmiter, R. D. et al. Nature 300, 611–615 (1982).
Gammon, G. et al. Immunol. Rev. 98, 53–73 (1987).
Hardy, R. R., Hayakawa, K., Parks, D. R. & Herzenberg, L. A. Nature 306, 270–272 (1983).
MacLennan, I. C. M. & Gray, D. Immunol. Rev. 91, 61–85 (1986).
Herzenberg, L. A. et al. Immunol. Rev. 93, 81–102 (1986).
Yuan, D. J. Immun. 132, 1566–1570 (1984).
Goodnow, C. C. et al. Cold Spring Harbor Symp. quant. Biol. (in the press).
Zan-Bar, I., Vitetta, E. S., Assisi, F. & Strober, S. J. exp. Med. 147, 1374–1394 (1978).
Bretscher, P. & Cohn, M. Science 163, 1042–1049 (1970).
Hari, J. & Roth, R. A. J. biol. Chem. 262, 15341 (1987).
Gill, G. N. et al. Cold Spring Harbor Symp. quant. Biol. 53, 467–476 (1988).
Williams, L. T., Escobedo, J. A., Keating, M. T. & Coughlin, S. R. Cold Spring Harbor Symp. quant. Biol. 53, 455–465 (1988).
Sherr, C. J., Rettenmier, C. W. & Roussel, M. F. Cold Spring Harbor Symp. quant. Biol. 53, 521–530 (1988).
Goroff, D. K., Stall, A., Mond, J. J. & Finkelman, F. D. J. Immun. 136, 2382–2392 (1986).
Cambier, J. C. et al. Immunol. Rev. 95, 37–57 (1987).
Cambier, J. C. et al. Proc. natl. Acad. Sci. U.S.A. 85, 6493–6497 (1988).
Lefkovitz, R. J. et al. Cold Spring Harbor Symp. quant. Biol. 53, 507–514 (1988).
Stryer, L. Cold Spring Harbor Symp. quant. Biol. 53, 283–294 (1988).
Mueller, D. L., Jenkins, M. K. & Schwartz, R. H. A. Rev. Immun. 7, 445–480 (1989).
Defranco, A. L., Gold, M. R. & Jakway, J. P. Immunol. Rev. 95, 161–176 (1987).
Hombach, J. et al. EMBO J. 7, 3451–3456 (1988).
Sakaguchi, N. et al. EMBO J. 7, 3457–3464 (1988).
Reth, M. Nature 338, 383–384 (1989).
Schüppel, R., Wilke, J. & Weiler, E. Eur. J. Immun. 17, 739–741 (1987).
Smith-Gill, S. J., Lavoie, T. B. & Mainhart, C. R. J. Immun. 133, 384–393 (1984).
Sedgwick, J. D. & Holt, P. G. J. immunol. Meth. 57, 301–311 (1983).
Hardy, R. R., Hayakawa, K., Haaijman, J. & Herzenberg, L. A. Nature 297, 589–591 (1982).
Herzenberg, L. A. et al. Nature 329, 71–73 (1987).
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Goodnow, C., Crosbie, J., Jorgensen, H. et al. Induction of self-tolerance in mature peripheral B lymphocytes. Nature 342, 385–391 (1989). https://doi.org/10.1038/342385a0
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DOI: https://doi.org/10.1038/342385a0
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