Abstract
MAMMALIAN sex chromosomes share a small terminal region of homologous DNA sequences, which pair and recombine during male meiosis (reviewed in ref. 1). Alleles in this region can be exchanged between X and Y chromosomes and are therefore inherited as if autosomal. Genes from this so-called pseudoautosomal region (PAR) are present in two doses in both males and females, and escape inactivation of the X chromosome in females. Indirect evidence suggests that there must be several pseudoautosomal genes, and several candidates have been proposed. Until now, the only gene that has been unequivocally located in the PAR is MIC2, which encodes a cell-surface antigen of unknown function2,3. We now report the localization of a gene of known function to this region—the gene for the receptor of the haemopoietic regulator, granulocyte-macrophage colony stimulating factor. The chromosomal localization of this gene may be important in understanding the generation of M2 acute myeloid leukaemia.
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References
Ellis, N. & Goodfellow, P. N. Trends Genet. 5, 406–410 (1989).
Goodfellow, P. J., Darling, S. M., Thomas, N. S. & Goodfellow, P. N. Science 234, 740–743 (1986).
Darling, S. M. et al. Cold Spring Harb. Symp. quant. Biol. 51, 205–212 (1986).
Gough, N. M. & Nicola, N. A. in Colony-Stimulating Factors: Molecular and Cellular Biology (eds Dexter, T. M., Garland, J. M. & Testa, N. G.) 111–153 (Marcel Dekker, New York, 1989).
Gearing, D. P., King, J. A., Gough, N. M. & Nicola, N. A. EMBO J. 8, 3667–3676 (1989).
Rouyer, F. et al. Nature 319, 291–295 (1986).
Koller, P. C. & Darlington, C. D. J. Genet. 29, 159–173 (1934).
Haldane, J. B. S. Ann. Eugen. 7, 28–57 (1936).
Ferguson-Smith, M. A. Birth Defects Orig. Artic. Ser. 5, 3–9 (1969).
Burgoyne, P. S. Hum. Genet. 61, 85–90 (1982).
Cooke, H. J., Brown, W. R. A. & Rappold, G. A. Nature 317, 687–692 (1985).
Simmler, M-C. et al. Nature 317, 692–697 (1985).
Rouyer, F. et al. Cold Spring Harb. Symp. quant. Biol. 51, 221–228 (1986).
Pritchard, C. A., Goodfellow, P. J. & Goodfellow, P. N. Nature 328, 273–275 (1987).
Brown, W. R. A. EMBO J. 7, 2377–2385 (1988).
Petit, C., Levilliers, J. & Weissenbach, J. EMBO J. 7, 2369–2376 (1988).
Crow, T. J. Br. J. Psychiatry 153, 675–683 (1988).
Crow, T. J. Lancet ii, 339–340 (1989).
Ferguson-Smith, M. A. J. med. Genet 2, 142–155 (1965).
Gelin, C. et al. EMBO J. 8, 3253–3259 (1989).
Goodfellow, P. J., Pritchard, C., Tippet, P. & Goodfellow, P. N. Ann. hum. Genet. 51, 161–167 (1987).
Mitelman, F. Catalogue of Chromosome Aberrations in Cancer, 3rd edn (Alan R. Liss, New York, 1988).
Ponder, B. Nature 335, 400–402 (1988).
Begley, C. G., Metcalf, D. & Nicola, N. A. Leukemia 1, 1–8 (1987).
Vellenga, E. et al. Blood 69, 1771–1776 (1987).
Vellenga, E., Delwel, M. R., Touw, J. P. and Löwenberg, B. Exp. Hemat. 15, 652–656 (1989).
Budel, L. M. et al. Blood 74, 565–571 (1989).
Onetto-Pothier, N. et al. Blood 75, 59–66 (1990).
Callen, D. F. et al. Genomics 2, 144–153 (1988).
Sutherland, G. R. et al. Cytogenet. Cell Genet. 50, 149–150 (1989).
Callen, D. F. et al. Genomics 4, 348–354 (1989).
Suthers, G. K. et al. Science 246, 1298–1300 (1989).
Nussbaum, R. L., Airhart, S. D. & Ledbetter, D. H. Hum. Genet. 64, 148–150 (1983).
Catalogue of Cell Lines (1988/1989) (NIGMS Human Genetic Mutant Cell Repository (NIH Publication 89-2011, Bethesda, 1989).
Sutherland, G. R. et al. Am. J. hum. Genet. 43, 331–335 (1988).
Callen, D. F. Ann. Génét. 29, 235–239 (1986).
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Gough, N., Gearing, D., Nicola, N. et al. Localization of the human GM-CSF receptor gene to the X–Y pseudoautosomal region. Nature 345, 734–736 (1990). https://doi.org/10.1038/345734a0
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DOI: https://doi.org/10.1038/345734a0
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