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Localization of the human GM-CSF receptor gene to the X–Y pseudoautosomal region

Abstract

MAMMALIAN sex chromosomes share a small terminal region of homologous DNA sequences, which pair and recombine during male meiosis (reviewed in ref. 1). Alleles in this region can be exchanged between X and Y chromosomes and are therefore inherited as if autosomal. Genes from this so-called pseudoautosomal region (PAR) are present in two doses in both males and females, and escape inactivation of the X chromosome in females. Indirect evidence suggests that there must be several pseudoautosomal genes, and several candidates have been proposed. Until now, the only gene that has been unequivocally located in the PAR is MIC2, which encodes a cell-surface antigen of unknown function2,3. We now report the localization of a gene of known function to this region—the gene for the receptor of the haemopoietic regulator, granulocyte-macrophage colony stimulating factor. The chromosomal localization of this gene may be important in understanding the generation of M2 acute myeloid leukaemia.

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References

  1. Ellis, N. & Goodfellow, P. N. Trends Genet. 5, 406–410 (1989).

    Article  CAS  Google Scholar 

  2. Goodfellow, P. J., Darling, S. M., Thomas, N. S. & Goodfellow, P. N. Science 234, 740–743 (1986).

    Article  ADS  CAS  Google Scholar 

  3. Darling, S. M. et al. Cold Spring Harb. Symp. quant. Biol. 51, 205–212 (1986).

    Article  CAS  Google Scholar 

  4. Gough, N. M. & Nicola, N. A. in Colony-Stimulating Factors: Molecular and Cellular Biology (eds Dexter, T. M., Garland, J. M. & Testa, N. G.) 111–153 (Marcel Dekker, New York, 1989).

    Google Scholar 

  5. Gearing, D. P., King, J. A., Gough, N. M. & Nicola, N. A. EMBO J. 8, 3667–3676 (1989).

    Article  CAS  Google Scholar 

  6. Rouyer, F. et al. Nature 319, 291–295 (1986).

    Article  ADS  CAS  Google Scholar 

  7. Koller, P. C. & Darlington, C. D. J. Genet. 29, 159–173 (1934).

    Article  Google Scholar 

  8. Haldane, J. B. S. Ann. Eugen. 7, 28–57 (1936).

    Article  Google Scholar 

  9. Ferguson-Smith, M. A. Birth Defects Orig. Artic. Ser. 5, 3–9 (1969).

    Google Scholar 

  10. Burgoyne, P. S. Hum. Genet. 61, 85–90 (1982).

    Article  CAS  Google Scholar 

  11. Cooke, H. J., Brown, W. R. A. & Rappold, G. A. Nature 317, 687–692 (1985).

    Article  ADS  CAS  Google Scholar 

  12. Simmler, M-C. et al. Nature 317, 692–697 (1985).

    Article  ADS  CAS  Google Scholar 

  13. Rouyer, F. et al. Cold Spring Harb. Symp. quant. Biol. 51, 221–228 (1986).

    Article  CAS  Google Scholar 

  14. Pritchard, C. A., Goodfellow, P. J. & Goodfellow, P. N. Nature 328, 273–275 (1987).

    Article  ADS  CAS  Google Scholar 

  15. Brown, W. R. A. EMBO J. 7, 2377–2385 (1988).

    Article  CAS  Google Scholar 

  16. Petit, C., Levilliers, J. & Weissenbach, J. EMBO J. 7, 2369–2376 (1988).

    Article  CAS  Google Scholar 

  17. Crow, T. J. Br. J. Psychiatry 153, 675–683 (1988).

    Article  CAS  Google Scholar 

  18. Crow, T. J. Lancet ii, 339–340 (1989).

    Article  Google Scholar 

  19. Ferguson-Smith, M. A. J. med. Genet 2, 142–155 (1965).

    Article  CAS  Google Scholar 

  20. Gelin, C. et al. EMBO J. 8, 3253–3259 (1989).

    Article  CAS  Google Scholar 

  21. Goodfellow, P. J., Pritchard, C., Tippet, P. & Goodfellow, P. N. Ann. hum. Genet. 51, 161–167 (1987).

    Article  CAS  Google Scholar 

  22. Mitelman, F. Catalogue of Chromosome Aberrations in Cancer, 3rd edn (Alan R. Liss, New York, 1988).

    Google Scholar 

  23. Ponder, B. Nature 335, 400–402 (1988).

    Article  ADS  CAS  Google Scholar 

  24. Begley, C. G., Metcalf, D. & Nicola, N. A. Leukemia 1, 1–8 (1987).

    CAS  PubMed  Google Scholar 

  25. Vellenga, E. et al. Blood 69, 1771–1776 (1987).

    CAS  PubMed  Google Scholar 

  26. Vellenga, E., Delwel, M. R., Touw, J. P. and Löwenberg, B. Exp. Hemat. 15, 652–656 (1989).

    Google Scholar 

  27. Budel, L. M. et al. Blood 74, 565–571 (1989).

    CAS  PubMed  Google Scholar 

  28. Onetto-Pothier, N. et al. Blood 75, 59–66 (1990).

    CAS  PubMed  Google Scholar 

  29. Callen, D. F. et al. Genomics 2, 144–153 (1988).

    Article  CAS  Google Scholar 

  30. Sutherland, G. R. et al. Cytogenet. Cell Genet. 50, 149–150 (1989).

    Article  CAS  Google Scholar 

  31. Callen, D. F. et al. Genomics 4, 348–354 (1989).

    Article  CAS  Google Scholar 

  32. Suthers, G. K. et al. Science 246, 1298–1300 (1989).

    Article  ADS  CAS  Google Scholar 

  33. Nussbaum, R. L., Airhart, S. D. & Ledbetter, D. H. Hum. Genet. 64, 148–150 (1983).

    Article  CAS  Google Scholar 

  34. Catalogue of Cell Lines (1988/1989) (NIGMS Human Genetic Mutant Cell Repository (NIH Publication 89-2011, Bethesda, 1989).

  35. Sutherland, G. R. et al. Am. J. hum. Genet. 43, 331–335 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  36. Callen, D. F. Ann. Génét. 29, 235–239 (1986).

    CAS  PubMed  Google Scholar 

Download references

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Gough, N., Gearing, D., Nicola, N. et al. Localization of the human GM-CSF receptor gene to the X–Y pseudoautosomal region. Nature 345, 734–736 (1990). https://doi.org/10.1038/345734a0

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