Abstract
The complementary DNA of a metabotropic glutamate receptor coupled to inositol phosphate/Ca2+ signal transduction has been cloned and characterized. This receptor shows no sequence similarity to conventional G protein-coupled receptors and has a unique structure with large hydrophilic sequences at both sides of seven putative membrane-spanning domains. Abundant expression of this messenger RNA is observed in neuronal cells in hippocampal dentate gyrus and CA2−3 and in cerebellar Purkinje cells, suggesting the importance of this receptor in specific hippocampal and cerebellar functions.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Monaghan, D. T., Bridges, R. J. & Cotman, C. W. A. Rev. Pharmac. Tox. 29, 365–402 (1989).
Watkins, J. C., Krogsgaard-Larsen, P. & Honoré, T. Trends pharmac. Sci. 11, 25–33 (1990).
Meldrum, B. & Garthwaite, J. Trends pharmac. Sci. 11, 379–387 (1990).
Sladeczek, F., Récasens, M. & Bockaert, J. Trends Neurosci. 11, 545–549 (1988).
Hollmann, M., O'Shea-Greenfield, A., Rogers, S. W. & Heinemann, S. Nature 342, 643–648 (1989).
Keinänen, K. et al. Science 249, 556–560 (1990).
Nicoletti, F., Iadarola, M. J., Wroblewski, J. T. & Costa, E. Proc. natn. Acad. Sci. U.S.A. 83, 1931–1935 (1986).
Sugiyama, H., Ito, I. & Hirono, C. Nature 325, 531–533 (1987).
Sugiyama, H., Ito, I. & Watanabe, M. Neuron 3, 129–132 (1989).
Masu, Y. et al. Nature 329, 836–838 (1987).
Dascal, N. CRC crit. Rev. Biochem. 22, 317–387 (1987).
Takumi, T., Ohkubo, H. & Nakanishi, S. Science 242, 1042–1045 (1988).
Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).
Kozak, M. Nucleic Acids Res. 15, 8125–8148 (1987).
O'Dowd, B. F., Lefkowitz, R. J. & Caron, M. G. A. Rev. Neurosci. 12, 67–83 (1989).
Nakanishi, S. et al. Recent Prog. Hormone Res. 46, 59–84 (1990).
McFarland, K. C. et al. Science 245, 494–499 (1989).
Sprengel, R. et al. Molec. Endocr. 4, 525–530 (1990).
von Heijne, G. Eur. J. Biochem. 133, 17–21 (1983).
Boyd, D. & Beckwith, J. Cell 62, 1031–1033 (1990).
Kitamura, N. et al. J. biol. Chem. 260, 8610–8617 (1985).
Hubbard, S. C. & Ivatt, R. J. A. Rev. Biochem. 50, 555–583 (1981).
Kemp, B. E. & Pearson, R. B. Trends biol. Sci. 15, 342–346 (1990).
Kishimoto, A. et al. J. biol. Chem. 260, 12492–12499 (1985).
Nicoll, R. A., Kauer, J. A. & Malenka, R. C. Neuron 1, 97–103 (1988).
Ito, M. A. Rev. Neurosci. 12, 85–102 (1989).
Ito, I., Okada, D. & Sugiyama, H. Neurosci. Lett. 90, 181–185 (1988).
Goh, J. W. & Pennefather, P. S. Science 244, 980–983 (1989).
Hwang, P. M., Bredt, D. S. & Snyder, S. H. Science 249, 802–804 (1990).
Ross, C. A., Bredt, D. & Snyder, S. H. Trends Neurosci. 13, 216–222 (1990).
Furuichi, T. et al. Nature 342, 32–38 (1989).
Kano, M. & Kato, M. Nature 325, 276–279 (1987).
Yokota, Y. et al. J. biol. Chem. 264, 17649–17652 (1989).
Varnold, R. L. & Smith, L. D. Development 109, 597–604 (1990).
Kyte, J. & Doolittle, R. F. J. molec. Biol. 157, 105–132 (1982).
Angerer, L. M., Cox, K. H. & Angerer, R. C. Meth. Enzym. 152, 649–661 (1987).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Masu, M., Tanabe, Y., Tsuchida, K. et al. Sequence and expression of a metabotropic glutamate receptor. Nature 349, 760–765 (1991). https://doi.org/10.1038/349760a0
Issue Date:
DOI: https://doi.org/10.1038/349760a0
This article is cited by
-
Targeting metabotropic glutamate receptors for novel treatments of schizophrenia
Molecular Brain (2017)
-
Glutamate, T cells and multiple sclerosis
Journal of Neural Transmission (2017)
-
Control of neuronal excitability by Group I metabotropic glutamate receptors
Biophysical Reviews (2017)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.