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Electron microscopy at 1-Å resolution by entropy maximization and likelihood ranking

Nature volume 355, pages 605–609 (1992)Cite this article

Abstract

The resolution of electron microscopy may be extended by combining the phase information in microscope images with electron diffraction intensities. A general method for obtaining structural reconstructions at a resolution greater than that of the phase information is demonstrated for crystals of perchlorocoronene. By using entropy maximization methods combined with likelihood ranking, the resolution is extended from 0.32 nm in the microscope images to 0.1 nm in the reconstruction from phase and intensity data.

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Authors and Affiliations

  1. Electron Microscope Centre, Chemistry Building, University of Glasgow, Glasgow, G12 8QQ, UK

    W. Dong, T. Baird & J. R. Fryer

  2. Chemistry Department, University of Glasgow, Glasgow, G12 8QQ, UK

    C. J. Gilmore & D. D. MacNicol

  3. MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK

    G. Bricogne

  4. Center for Solid State Science, Arizona State University, Tempe, Arizona, 85287, USA

    David J. Smith

  5. National Center for Electron Microscopy, University of California, LBL, Berkeley, California, 94720, USA

    M. A. O'Keefe

  6. Structural Chemistry, University of Stockholm, S-10691, Stockholm, Sweden

    S. Hövmoller

  7. LURE, Bâtiment 209D, 91405, Orsay, France

    J. R. Fryer, C. J. Gilmore & G. Bricogne

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  1. W. Dong
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  2. T. Baird
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  3. J. R. Fryer
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  5. D. D. MacNicol
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  6. G. Bricogne
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  7. David J. Smith
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  8. M. A. O'Keefe
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  9. S. Hövmoller
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Dong, W., Baird, T., Fryer, J. et al. Electron microscopy at 1-Å resolution by entropy maximization and likelihood ranking. Nature 355, 605–609 (1992). https://doi.org/10.1038/355605a0

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