Abstract
Antisense oligodeoxynucleotides (ODNs) have great promise as agents for the specific manipulation of gene expression. Until recently, nonspecific effects of ODNs often confounded the interpretation of antisense studies. Improvements in ODN chemistry and cellular delivery techniques now allow for more potent and specific gene inhibition. This review critically evaluates recent progress in the development of antisense ODNs.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Milligan, J. F., Matteucci, M. D. & Martin, J. C. J. med. Chem. 36, 1923–1937 (1993).
Stein, C. A. & Cheng, Y.-C. Science 261, 1004–1012 (1993).
Helene, C. & Toulme, J. Biochim. biophys. Acta 1049, 99–125 (1990).
Abe, J. et al. Biochem. biophys. Res. Commun. 198, 16–24 (1994).
Amaratunga, A., Morin, P. J., Kosik, K. S. & Fine, R. E. J. biol. Chem. 268, 17427–17430 (1993).
Bayever, E. et al. Antisense Res. Dev. 3, 383–390 (1993).
Bennett, M. R. et al. J. clin. Invest. 93, 820–828 (1994).
Chiasson, B. J., Hooper, M. L., Murphy, P. R. & Robertson, H. A. Eur. J. Pharmac. 227, 451–453 (1992).
Kitajima, I. et al. J. biol. Chem. 267, 25881–25888 (1992).
Kitajima, I. et al. Science 258, 1792–1795 (1992).
McCarthy, M. M., Masters, D. B., Rimvall, K., Schwartz-Giblin, S. & Pfaff, D. W. Brain Res. 636, 55–58 (1994).
Morishita, R. et al. Proc. natn. Acad. Sci. U.S.A. 90, 8474–8478 (1993).
Morishita, R. et al. J. clin. Invest 93, 1458–1464 (1994).
Offensperger, W. B. et al. EMBO J. 12, 1257–1262 (1993).
Osen-Sand, A. et al. Nature 364, 445–448 (1993).
Perlaky, L. et al. Anticancer Drug Des. 8, 3–14 (1993).
Simons, M., Edelman, E. R., De Keyser, J. L., Langer, R. & Rosenberg, R. D. Nature 359, 67–70 (1992).
Simons, M., Edelman, E. R. & Rosenberg, R. D. J. clin. Invest. 93, 2351–2356 (1994).
Skutella, T., Probst, J. C., Jirikowski, G. F., Holsboer, F. & Spanagel, R. Neurosci. Lett. 167, 55–58 (1994).
Standifer, K. M., Chien, C. C., Wahlestedt, C., Brown, G. P. & Pasternak, G. W. Neuron 12, 805–810 (1994).
Whitesell, L., Rosolen, A. & Neckers, L. M. Antisense Res. Dev. 1, 343–350 (1991).
Zhou, L. W., Zhang, S. P., Qin, Z. H. & Weiss, B. J. pharmac. exp. Ther. 268, 1015–1023 (1994).
Higgins, K. A. et al. Proc. natn. Acad. Sci. U.S.A. 90, 9901–9905 (1993).
Hijiya, N. et al. Proc. natn. Acad. Sci. U.S.A. 91, 4499–4503 (1994).
Skorski, T. et al. Proc. natn. Acad. Sci. U.S.A. 91, 4504–4508 (1994).
Shi, Y. et al. Circulation 90, 944–951 (1994).
Alper, J. Biotechnology 11, 1225 (1993).
Maister, P. Bioworld Today 5, 3 (1994).
Woolf, T. M., Melton, D. A. & Jennings, C. G. Proc. natn. Acad. Sci. U.S.A. 89, 7305–7309 (1992).
Ellington, A. D. & Szostak, J. W. Nature 346, 818–822 (1990).
Gao, W.-Y., Han, F.-S., Storm, C., Egan, W. & Cheng, Y.-C. Molec. Pharmac. 41, 223–229 (1992).
Bock, L. C., Griffin, L. C., Latham, J. A., Vermaas, E. H. & Toole, J. J. Nature 355, 564–566 (1992).
Yakubov, L. et al. J. biol. Chem. 268, 18818–18823 (1993).
Perez, J. R. et al. Proc. natn. Acad. Sci. U.S.A. 91, 5957–5961 (1994).
Yao, G.-Q., Grill, S., Egan, W. & Cheng, Y.-C. Antimicrob. Agents Chemother. 37, 1420–1425 (1993).
Azad, R. F., Driver, V. B., Tanaka, K., Crooke, R. M. & Anderson, K. P. Antimicrob. Agents Chemother. 37, 1945–1954 (1993).
Rathbone, M. P. et al. In Vitro Cell dev. Biol. 28A, 529–536 (1992).
Kamano, H. et al. Biochem. Int. 26, 537–543 (1992).
Shaw, J. P., Kent, K., Bird, J., Fishback, J. & Froehler, B. Nucleic Acids Res. 19, 747–750 (1991).
Fisher, T. L., Terhorst, T., Cao, X. & Wagner, R. W. Nucleic Acids Res. 21, 3857–3865 (1993).
Agrawal, S., Temsamani, J. & Tang, J. Y. Proc. natn. Acad. Sci. U.S.A. 88, 7595–7599 (1991).
Wagner, R. W. et al. Science 260, 1510–1513 (1993).
Kirkland, M. A. et al. Lancet 342, 614 (1993).
Stein, C. A. Leukemia 6, 967–974 (1992).
Dean, N. M., McKay, R., Condon, T. P. & Bennett, C. F. J. biol. Chem. 269, 16416–16424 (1994).
Bennett, C. F., Condon, T. P., Grimm, S., Chan, H. & Chiang, M.-Y. J. Immun. 152, 3530–3540 (1994).
Fenster, S. D., Wagner, R. W., Froehler, B. C. & Chin, D. J. Biochemistry 33, 8391–8398 (1994).
Bennett, C. F., Chiang, M. Y., Chan, H., Shoemaker, J. E. & Mirabelli, C. K. Molec. Pharmac. 41, 1023–1033 (1992).
Colige, A., Sokolov, B. P., Nugent, P., Baserga, R. & Prockop, D. J. Biochemistry 32, 7–11 (1993).
Monia, B. P. et al. J. biol. Chem. 268, 14514–14522 (1993).
Epstein, S. E., Speir, E. & Finkel, T. Circulation 88, 1351–1353 (1993).
Chiang, M. Y. et al. J. biol. Chem. 266, 18162–18171 (1991).
Piatak, J. M. et al. Science 259, 1749–1754 (1993).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wagner, R. Gene inhibition using antisense oligodeoxynucleotides. Nature 372, 333–335 (1994). https://doi.org/10.1038/372333a0
Issue Date:
DOI: https://doi.org/10.1038/372333a0
This article is cited by
-
Suppression of prostate tumor cell survival by antisense oligonucleotide-mediated inhibition of AR-V7 mRNA synthesis
Oncogene (2019)
-
Intracellular oligonucleotide delivery using the cell penetrating peptide Xentry
Scientific Reports (2018)
-
Regulation of Connexin43 Gap Junction Protein Triggers Vascular Recovery and Healing in Human Ocular Persistent Epithelial Defect Wounds
The Journal of Membrane Biology (2012)
-
Increased expression of heat shock protein 105 in rat uterus of early pregnancy and its significance in embryo implantation
Reproductive Biology and Endocrinology (2009)
-
Antisense-Oligonukleotide zur Therapie der Mukoviszidose
HNO (2009)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.