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Expression of Radical fringe in limb-bud ectoderm regulates apical ectodermal ridge formation

Nature volume 386, pages 366–373 (1997)Cite this article

A Corrigendum to this article was published on 24 July 1997

Abstract

The apical ectodermal ridge of the vertebrate limb bud lies at the junction of the dorsal and ventral ectoderm and directs patterning of the growing limb. Its formation is directed by the boundary between cells that do and cells that do not express the gene Radical fringe. This is similar to the establishment of the margin cells at the Drosophila wing dorsoventral border by fringe. Radical fringe expression in chick-limb dorsal ectoderm is established in part through repression by Engrailed-1 in the ventral ectoderm.

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Author information

Authors and Affiliations

  1. Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts, 02115, USA

    Ed Laufer, Olivia E. Orozco, Chang-Yeol Yeo & Cliff Tabin

  2. Department of Anatomy, University of Wisconsin, 1300 University Avenue, Madison, Wisconsin, 53706, USA

    Randall Dahn & John F. Fallon

  3. Department of Avian Sciences, University of California, Davis, Davis, California, 95616, USA

    Jacqueline Pisenti & Ursula K. Abbott

  4. Developmental Genetics Laboratory, Imperial Cancer Research Fund, PO Box 123, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK

    Domingos Henrique

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Laufer, E., Dahn, R., Orozco, O. et al. Expression of Radical fringe in limb-bud ectoderm regulates apical ectodermal ridge formation . Nature 386, 366–373 (1997). https://doi.org/10.1038/386366a0

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