Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cancer

Trouble upstream

Nature volume 495, pages 320–321 (2013)Cite this article

Subjects

Mutations in the promoter sequence of the gene encoding a component of the enzyme telomerase have been discovered in patients with melanoma, suggesting that mutations in this regulatory region can drive tumour development.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Promoter mutations create new transcription-factor binding sites.

References

  1. Huang, F. W. et al. Science 339, 957–959 (2013).

    Article  ADS  CAS  Google Scholar 

  2. Horn, S. et al. Science 339, 959–961 (2013).

    Article  ADS  CAS  Google Scholar 

  3. Pleasance, E. D. et al. Nature 463, 191–196 (2010).

    Article  ADS  CAS  Google Scholar 

  4. Hodis, E. et al. Cell 150, 251–263 (2012).

    Article  CAS  Google Scholar 

  5. Krauthammer, M. et al. Nature Genet. 44, 1006–1014 10.1038/ng.2359 (2012).

    Article  CAS  PubMed  Google Scholar 

  6. Harrington, L. Mutat. Res. 730, 37–42 (2012).

    Article  CAS  Google Scholar 

  7. Ding, Z. et al. Cell 148, 896–907 (2012).

    Article  CAS  Google Scholar 

  8. Jané-Valbuena, J. et al. Cancer Res. 70, 2075–2084 (2010).

    Article  Google Scholar 

  9. Capper, R. et al. Genes Dev. 21, 2495–2508 (2007).

    Article  CAS  Google Scholar 

  10. Xu, L. & Blackburn, E. H. Mol. Cell 28, 315–327 (2007).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. E. Elizabeth Patton is at the MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK.,

    E. Elizabeth Patton

  2. Lea Harrington is at the Wellcome Trust Centre for Cell Biology, Edinburgh EH9 3JR, UK, and the Institute for Research in Immunology and Cancer, University of Montreal, Canada.,

    Lea Harrington

Authors
  1. E. Elizabeth Patton
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lea Harrington
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to E. Elizabeth Patton or Lea Harrington.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Patton, E., Harrington, L. Trouble upstream. Nature 495, 320–321 (2013). https://doi.org/10.1038/495320a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/495320a

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer