Effects of Hypothyroidism and Progesterone on Mammary Tumours Induced by 7,12-Dimethylbenz(a)anthracene in Sprague-Dawley Rats

Abstract

Hypothyroidism, alone or combined with progesterone, significantly decreased 7,12-dimethylbenz(a)anthracene (DMBA) mammary tumorigenesis relative to controls. However, the decrease was less in the progesterone-treated group, and statistical analysis showed that progesterone enhanced tumorigenesis to the same extent in hypothyroid animals as in the controls. Most tumours in hypothyroid progesterone-treated rats were adenocarcinomata; in the absence of the hormone most tumours were benign. However, the difference between the tumour types in the 2 groups was not statistically significant.

The morphological changes observed in the endocrine glands, genital tracts and non-neoplastic mammary tissue, considered in relation to previously reported data, suggest that hypothyroidism reduced the tumour yield mainly by secondarily inhibiting somatotrophin production and secretion, although the effect of decreased food intake could not be excluded completely. The higher tumour yield in the hypothyroid progesterone-treated rats may have been due to higher circulating levels of prolactin in this group compared with those in the hypothyroid group which received no hormone.