Abstract
SINCE the discovery of the hepatotoxic1 and carcinogenic2 effect of dimethylnitrosamine (DMN), the significance of various nitroso-compounds as potential carcinogens in man has aroused increasing attention3–8, especially since the demonstration of the endogenous production of nitrosocarcinogens from dietary amines or amides and sodium nitrite9–15. Cellular damage resulting from exposure to nitrosamines has been attributed to unidentified metabolite(s) which alkylate nucleic acids, rather than to the parent compounds themselves16–18 and certain agents (for example, aminoacetonitrile19–21, polycyclic aromatic hydrocarbons22,23, protein-free diet24,25) which inhibit the metabolic degradation of DMN were subsequently found to reduce its acute toxicity and hepatocarcinogenicity.
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SOMOGYI, A., CONNEY, A., KUNTZMAN, R. et al. Protection against Dimethylnitrosamine Toxicity by Pregnenolone-16α-Carbonitrile. Nature New Biology 237, 61–63 (1972). https://doi.org/10.1038/newbio237061a0
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DOI: https://doi.org/10.1038/newbio237061a0
