Abstract
Tyrothricin specifically inhibits RNA synthesis in growing cultures of Bacillus brevis as well as purified RNA polymerase. This suggests that the peptide antibiotic may function in the regulation of gene transcription during the transition from vegetative growth to sporulation.
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References
Watanabe, T., Bact. Rev., 27, 87 (1963).
Waksman, S. A., Perspectives in Biol. and Med., 4, 271 (1961).
Harwood, J., & Smith, D. H., Biochem. Biophys. Res. Commun., 42, 57 (1971).
Dhar, M. M., & Khan, A. W., Nature, 233, 182 (1971).
Weinberg, E. D., Perspectives in Biol, and Med., 14, 565 (1971).
Lipmann, F., Science, 173, 875 (1971).
Bu'Lock, J. D., Adv. Appl. Microbiol., 3, 293 (1961).
Schaeffer, P., Bact. Rev., 33, 48 (1969).
Paulus, H., in Antibiotics (edit. by Gottlieb, D., and Shaw, P. D.), 2, 254 (Springer, Berlin, 1967).
Bhattacharyya, P., & Bose, S. K., J. Gen. Appl. Microbiol., 15, 473 (1969).
Jann, G. J., & Eichhorn, H. H., Bact. Proc., 13 (1964).
Bernlohr, R. W., & Novelli, G. D., Biochim. Biophys. Acta, 41, 541 (1962).
Snoke, J. E., Biochem. Biophys. Res. Commun., 14, 571 (1964).
Marschke, C. K., & Bernlohr, R. W., J. Bact., 102, 283 (1970).
Brenner, M., Gray, E., & Paulus, H., Biochim. Biophys. Acta, 90, 401 (1964).
Bhattacharyya, P., & Bose, S. K., J. Bact., 94, 2079 (1967).
Yoshida, T., Weissbach, H., & Katz, E., Arch. Biochem. Biophys., 114, 252 (1966).
Snoke, J. E., & Cornell, N., J. Bact., 89, 415 (1965).
Schmitt, R., & Freese, E., J. Bact., 96, 1255 (1968).
Hotchkiss, R. D., Adv. Enzymol., 4, 153 (1944).
Mach, B., Reich, E., & Tatum, E. L., Proc. US Nat. Acad. Sci., 50, 175 (1963).
Hanson, R. S., Blicharska, J., & Szulmajster, J., Biochem. Biophys. Res. Commun., 17, 1 (1964).
Losick, R., Shorenstein, R. G., & Sonenshein, A. L., Nature, 227, 910 (1970).
Maia, J. C. C., Kerjan, P., & Szulmajster, J., FEBS Lett., 13, 269 (1971).
Avila, J., Hermoso, J. M., Vinuela, E., & Salas, M., Europ. J. Biochem., 21, 526 (1971).
Babinet, C., Biochem. Biophys. Res. Commun., 26, 639 (1967).
Hunter, R. E., & Schwarz, L. S., in Antibiotics (edit. by Gottlieb, D., and Shaw, P. D.), 1, 636 (Springer, Berlin, 1967).
Janssen, F. W., Lund, A. J., & Anderson, L. E., Science, 127, 26 (1958).
Doi, R. H., & Igarashi, R. T., Proc. US Nat. Acad. Sci., 52, 755 (1964).
Losick, R., & Sonenshein, A. L., Nature, 224, 35 (1969).
Hussey, C., Losick, R., & Sonenshein, A. L., J. Mol. Biol., 57, 59 (1971).
Schaeffer, P., Millet, J., & Aubert, J. P., Proc. US Nat. Acad. Sci., 54, 704 (1965).
Elmerich, C., & Aubert, J. P., Biochem. Biophys. Res. Commun., 46, 892 (1972).
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SARKAR, N., PAULUS, H. Function of Peptide Antibiotics in Sporulation. Nature New Biology 239, 228–230 (1972). https://doi.org/10.1038/newbio239228a0
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DOI: https://doi.org/10.1038/newbio239228a0
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