Abstract
THE prostaglandins (PG) are possible mediators of inflammation. Prostaglandins E and F are present in inflammatory exudates1–3 and could be related to the increase of collagen biosynthesis associated with inflammation. Vane and his colleagues4–6 recently observed that indomethacin, aspirin and sodium salicylate potently block the biosynthesis of prostaglandins. These anti-inflammatory drugs are also inhibitors of collagen biosynthesis7,8. Morphological studies9 have revealed increased deposition of collagen or collagen-related elements in organ cultures of chick embryo skin containing prostaglandins E1 and B1. We report here results which indicate stimulation of collagen biosynthesis by prostaglandins E1 and F1α evaluated by hydroxylation of proline and lysine and glycosylation of hydroxylysine in 10 day chick embryo tibiae.
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BLUMENKRANTZ, N., SØNDERGAARD, J. Effect of Prostaglandins E1 and F1α on Biosynthesis of Collagen. Nature New Biology 239, 246 (1972). https://doi.org/10.1038/newbio239246a0
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DOI: https://doi.org/10.1038/newbio239246a0
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