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Release of Bone Marrow Colony Stimulating Activity during Immunological Reactions in vitro

Nature New Biology volume 244, pages 175–176 (1973)Cite this article

Abstract

INTERFERON inhibits the development of granulocyte/macrophage colonies in vitro1–3. Colony stimulating (CS) factor, necessary for in vitro growth of colonies from their progenitor cells, and interferon seem to have antagonistic effects in this system (ref. 3 and preceding letter19). As interferon is released during the later stages of some immunological reactions in vitro4 and inhibits DNA synthesis in such cultures5 I studied the possibility that CS factor could be involved in these reactions. Unstimulated cultures of spleen, thymus and bone marrow cells spontaneously produce CS factor, but our experiments show that the amount increases when certain %are stimulated by allogeneic cells, soluble antigen (PPD) or phyto-haemagglutinin (PHA).

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  1. Department of Microbiology, The Queen's University of Belfast, Grosvenor Road, Belfast, BT12 6BN

    T. A. MCNEILL

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  1. T. A. MCNEILL
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MCNEILL, T. Release of Bone Marrow Colony Stimulating Activity during Immunological Reactions in vitro. Nature New Biology 244, 175–176 (1973). https://doi.org/10.1038/newbio244175a0

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