Abstract
As the renal vascular beds of dog and man have been shown to contain inhibitory receptors which seem to be specific for dopamine (DA)1,2 and the kidneys of a number of species contain high levels of DA 3,4, it has been suggested that DA may constitute an endogenous vasodilator factor in the regulation of renal function2,5. The existence in the central nervous system of neurones which seem to use DA as a transmitter has been established by histochemical and biochemical techniques6, and it is reasonable to consider that if DA were concerned in renal vascular control then this might be mediated through dopaminergic nerves. On the other hand, studies in which renal blood flow has been measured during stimulation of the peripheral renal nerves have not succeeded in demonstrating the existence of any vasodilator innervation of the renal vasculature7–9. We have adopted a different approach to this question by recording renal blood flow while electrically stimulating specific loci in the mid-brain and hypothalamus.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
We are sorry, but there is no personal subscription option available for your country.
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
McDonald, R. H. jun., Goldberg, L. I., McNay, J. L., and Tuttle, E. P. jun., J. clin. Invest., 43, 1116 (1964).
McNay, J. L., McDonald, R. H. jun., and Goldberg, L. I., Circulation Res., 16, 510 (1965).
Anton, A. H., and Sayre, D. F., J. Pharmac. exp. Ther., 145, 326 (1964).
Wegmann, A., Naunyn-Schmiedebergs Arch, exp. Path. Pharmak., 246, 184 (1963).
Cuche, J. L., Kuchel, O., Berbeau, A., Boucher, R., and Genest, J., Clin. Sci., 43, 481 (1972).
Hillarp, N-Å., Fuxe, K., and Dahlström, A., Pharmac. Rev., 18, 727 (1966).
Gomer, S. K., and Zimmerman, B. G., J. Pharmac. exp. Ther., 181, 75 (1972).
Takeuchi, J., Aoki, S., Nomura, G., Mizumura, H., Shimizu, H., and Kubo, T., J. appl. Physiol., 31, 686 (1971).
Concha, J., and Norris, B., Br. J. Pharmac. Chemother., 34, 277 (1968).
Uvnäs, B., Circulation Res., 22 and 23, Suppl. I, 83 (1967).
Bell, C., Lang, W. J., and Tsilemanis, C., Brain Res., 56, 392 (1973).
Yeh, B. K., McNay, J. L., and Goldberg, L. L., J. Pharmac. exp. Ther., 168, 303 (1969).
Espiritu, C. R., Mendoza, J. P., and Yeh, B. K., Proc. Soc. exp. Biol. Med., 141, 331 (1972).
Kelly, M. J., Br. J. Pharmac. Chemother., 46, 575P (1972).
Strandhoy, J. W., Cronelly, R., Long, J. P., and Williamson, H. E., Proc. Soc. exp. Biol. Med., 141, 336 (1972).
Zaroslinski, J. F., and Browne, R. K., Pharmacologist, 13, 227 (1971).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BELL, C., LANG, W. Neural Dopaminergic Vasodilator Control in the Kidney. Nature New Biology 246, 27–29 (1973). https://doi.org/10.1038/newbio246027a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/newbio246027a0
This article is cited by
-
Decrease of catecholamine and neuropeptide Y-like immunoreactivity in the glycerol-induced acute renal failure of rats
Research in Experimental Medicine (1990)
-
The effects of intravenous L-dopa on plasma renin activity, renal function, and blood pressure in man
European Journal of Clinical Pharmacology (1988)
-
Aldosterone and dopamine receptors in the kidney: Sites for pharmacologic manipulation of renal function
Kidney International (1980)