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Deficient diet evokes nasty heart virus

Nature Medicine volume 1, pages 405–406 (1995)Cite this article

Infection of mice on a selenium-deficient diet with a nonvirulent Coxsackievirus selects a stable cardiovirulent strain (pages 433–436).

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References

  1. Pallansch, M. Epidemiology of group B Coxsackieviruses. in Coxsackieviruses — A General Update (eds Bendinelli, M. & Friedman, H.) 399–417 (Plenum, New York, 1988).

    Chapter  Google Scholar 

  2. Kaplan, M.H., Klein, S.W., McPhee, J. & Harper, R.G. Group B Coxsackievirus infections in infants younger than three months of age: a serious childhood illness. Rev. infect. Dis. 5, 1019–1032 (1983).

    Article  CAS  PubMed  Google Scholar 

  3. Ge, K.Y. et al. The protective effect of selenium against viral myocarditis in mice. in Selenium in Biology and Medicine – Part B (eds Combs, G.F., Spallholz, J.E., Levander, O.A. & Oldfield, J.E.), 761–768 (Van Nostrand/Reinhold, New York, 1987).

    Google Scholar 

  4. Beck, M.A. et al. Benign human enterovirus bcomes virulent in selenium-deficient mice. J. med. Virol. 43, 166–170 (1994).

    Article  CAS  PubMed  Google Scholar 

  5. Beck, M.A., Shi, Q., Morris, V.C. & Levander, O.A. Rapid genomic evolution of a non-virulent Coxsackievirus B3 in selenium-deficient mice results in selection of identical virulent isolates. Nature Med. l, xxx–xxx (1995).

    Google Scholar 

  6. Chapman, N.M., Tu, Z., Tracy, S. & Gauntt, C.J. An infectious cDNA copy of the genome of a non-cardiovirulent Coxsackievirus B3 strain: Its complete sequence analysis and comparison to the genomes of cardiovirulent Coxsackieviruses. Arch. Virol. 135, 115–130 (1994).

    Article  CAS  PubMed  Google Scholar 

  7. Evans, D.M.A. et al. A single nucleotide change in the 5′ non-coding region of the genome of the Sabin type 3 poliovaccine is associated with increased neurovirulence. Nature 314, 548–550 (1985).

    Article  CAS  PubMed  Google Scholar 

  8. Almond, J.W. The attenuation of poliovirus neurovirulence. Anna. Rev. Microbiol. 41, 153–180 (1987).

    Article  CAS  Google Scholar 

  9. Caggana, M., Chan, P. & Ramsingh, A. Identification of a single amino acid residue in the capsid protein VP1 of Coxsackievirus B4 that determines the virulent phenotype. J. Virol. 67, 4797–4803 (1993).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Zurbriggen, A., Thomas, C., Yamada, M., Roos, R. & Fujinami, T. Direct evidence for a role for amino acid 101 of VP-1 in central nervous system disease in Theiler's murine encephalomyelitis virus infection. J. Virol. 65, 1929–1937 (1991).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Burk, R.F. & Hill, K.E., Selenoprotein, P. A selenium-rich extracellular glycoprotein. J. Nutr. 124, 1891–1897 (1994).

    Article  CAS  PubMed  Google Scholar 

  12. Michiels, C., Raes, M., Toussaint, O. & Remacle, J. Importance of Se-glutathione peroxidase, catalase, and Cu/Zn-SOD for cell survival against oxidative stress [Review]. Free Radic. Biol Med. 17, 235–248 (1994).

    Article  CAS  PubMed  Google Scholar 

  13. Konz, K.-H., Haap, M., Hill, K.E., Burk, R.F. & Walsh, R.A. Diastolic dysfunction of perfused rat hearts induced by hydrogen peroxide. Protective effect of selenium. J. mol. Cell. Cardiol. 21, 789–795 (1989).

    Article  CAS  PubMed  Google Scholar 

  14. Christensen, M.J. & Pusey, N.W. Binding of nuclear proteins to transcription regulatory elements in selenium deficiency. Biochim. biophys. Acta 1225, 338–341 (1994).

    Article  CAS  PubMed  Google Scholar 

  15. Schrauzer, G.N. Mechanistic aspects of anticarcinogenic action [Review]. Biol. Trace Elem. Res. 33, 51–62 (1992).

    Article  CAS  PubMed  Google Scholar 

  16. Beck, M.A., Kolbeck, P.C., Rohr, L.H., Shi, Q., Morris, V.C. & Levander, O.A. Vitamin E deficiency intensifies the myocardial injury of Coxsackievirus B3 infection of mice. J. Nutr. 124, 345–358 (1994).

    Article  CAS  PubMed  Google Scholar 

  17. Committee on Infectious Diseases, American Academy of Pediatrics. Measles in 1994 Red Book: Report of the Committee on Infectious Diseases (eds. Peter, G., Halsey, N.A., Marcuse, E.K., Pickering, L.K.) 23rd edn, 310–311 (American Academy of Pediatrics, Elk Grove Village, Illinois, 1994).

  18. Gauntt, C. et al. Molecular mimicry, anti-Coxsackievirus B3 neutralizing monoclonal antibodies and myocarditis. J. Immun. 154, 2983–2995 (1995).

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Microbiology, The University of Texas Health Science Center, San Antonio, Texas, 78284, USA

    Charles Gauntt

  2. Department of Pathology and Microbiology, The University of Nebraska Medical Center, Omaha, Nebraska, 68198, USA

    Steven Tracy

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  1. Charles Gauntt
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Gauntt, C., Tracy, S. Deficient diet evokes nasty heart virus. Nat Med 1, 405–406 (1995). https://doi.org/10.1038/nm0595-405

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