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Dyskinesias following neural transplantation in Parkinson's disease

Nature Neuroscience volume 5, pages 627–628 (2002)Cite this article

Abstract

Severe dyskinesias during the 'off' phases (periods of increased Parkinson's disease (PD) disability) have been observed following intrastriatal transplantation of human embryonic mesencephalic tissue1. Here we retrospectively analyzed 14 patients who were followed for up to 11 years after grafting, and found that dyskinesias (abnormal involuntary movements and postures) increased during postoperative off phases, but were generally of mild to moderate severity. Dyskinesia severity was not related to the magnitude of graft-derived dopaminergic re-innervation, as judged by 18F-labeled 6-L-fluorodopa (FD) positron emission tomography (PET), indicating that off-phase dyskinesias probably did not result from excessive growth of grafted dopaminergic neurons.

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Acknowledgements

This study was supported by the British and Swedish Medical Research Council, the United Kingdom Parkinson's Disease Society, the Gemeinnützige Hertie Stiftung, the Skane County Council Research and Development Foundation and the Kock, Wiberg, Söderberg and King Gustav V and Queen Victoria Foundations.

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Authors and Affiliations

  1. Section of Restorative Neurology, Wallenberg Neuroscience Center, Lund, SE-221 84, Sweden

    Peter Hagell & Olle Lindvall

  2. Division of Neurobiology, Wallenberg Neuroscience Center, Lund, SE-221 84, Sweden

    Anders Björklund

  3. Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund, SE-221 84, Sweden

    Patrik Brundin & Håkan Widner

  4. Division of Neurology, Department of Clinical Neuroscience, University Hospital, Lund, SE-221 85, Sweden

    Peter Hagell, Håkan Widner & Olle Lindvall

  5. Division of Neurosurgery, Department of Clinical Neuroscience, University Hospital, Lund, SE-221 85, Sweden

    Stig Rehncrona

  6. MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK

    Paola Piccini, Nicola Pavese & David J. Brooks

  7. National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK

    Lesley Crabb

  8. Sobell Department of Motor Neuroscience and Movement Disorders, Queen Square, London, WC1N 3BG, UK

    Niall Quinn

  9. Department of Neurology, University of Marburg, Marburg, DE-35033, Germany

    Wolfgang H. Oertel

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  1. Peter Hagell
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  2. Paola Piccini
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  3. Anders Björklund
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  7. Lesley Crabb
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  10. Niall Quinn
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  11. David J. Brooks
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  12. Olle Lindvall
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Corresponding author

Correspondence to Olle Lindvall.

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The authors declare no competing financial interests.

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Hagell, P., Piccini, P., Björklund, A. et al. Dyskinesias following neural transplantation in Parkinson's disease. Nat Neurosci 5, 627–628 (2002). https://doi.org/10.1038/nn863

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