Abstract
Making molecular machines that can be useful in the macroscopic world is a challenging long-term goal of nanoscience1. Inspired by the protein machinery found in biological systems2,3, and based on the theoretical understanding of the physics of motion at the nanoscale4,5, organic chemists have developed a number of molecules that can produce work by contraction or rotation when triggered by various external chemical or physical stimuli6,7,8,9. In particular, basic molecular switches that commute between at least two thermodynamic minima and more advanced molecular motors that behave as dissipative units working far from equilibrium when fuelled with external energy10,11,12,13 have been reported. However, despite recent progress14,15,16,17, the ultimate challenge of coordinating individual molecular motors in a continuous mechanical process that can have a measurable effect at the macroscale has remained elusive18,19. Here, we show that by integrating light-driven unidirectional molecular rotors as reticulating units in a polymer gel, it is possible to amplify their individual motions to achieve macroscopic contraction of the material. Our system uses the incoming light to operate under far-from-equilibrium conditions, and the work produced by the motor in the photostationary state is used to twist the entangled polymer chains up to the collapse of the gel. Our design could be a starting point to integrate nanomotors in metastable materials to store energy and eventually to convert it.
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References
Feynman, R. There's plenty of room at the bottom. Caltech Eng. Sci. 23, 22–36 (1960).
Schliwa, M. & Woehlke, G. Molecular motors. Nature 422, 759–765 (2003).
Vale, R. D. & Milligan, R. A. The way things move: looking under the hood of molecular motor proteins. Science 288, 88–95 (2000).
Jülicher, F., Ajdari, A. & Prost, J. Modeling molecular motors. Rev. Mod. Phys. 69, 1269–1281 (1997).
Astumian, R. D. Thermodynamic and kinetics of a Brownian motor. Science 276, 917–922 (1997).
Guix, M., Mayorga-Martinez, C. C. & Merkoçi, A. Nano/micromotors in (bio)chemical science applications. Chem. Rev. 114, 6285–6322 (2014).
Coskun, A., Banaszak, M., Astumian, R. D., Stoddart, J. F. & Grzybowski, B. A. Great expectations: can artificial molecular machines deliver on their promise? Chem. Soc. Rev. 41, 19–30 (2012).
Kay, E. R., Leigh, D. A. & Zerbetto, F. Synthetic molecular motors and mechanical machines. Angew. Chem. Int. Ed. 46, 72–191 (2007).
Seeman, N. C. DNA in a material world. Nature 421, 427–431 (2003).
Reinmann, P. Brownian motors: noisy transport far from equilibrium. Phys. Rep. 361, 57–265 (2002).
Li, H. et al. Relative unidirectional translation in an artificial molecular assembly fueled by light. J. Am. Chem. Soc. 135, 18609–18620 (2013).
Balzani, V. et al. Autonomous artificial nanomotor powered by sunlight. Proc. Natl Acad. Sci. USA 103, 1178–1183 (2006).
Koumura, N., Zijlstra, R. W., van Delden, R. A., Harada, N. & Feringa, B. L. Light-driven monodirectional molecular motor. Nature 401, 152–155 (1999).
Du, G., Moulin, E., Jouault, N., Buhler, E. & Giuseppone, N. Muscle-like supramolecular polymers: integrated motion from thousands of molecular machines. Angew. Chem. Int. Ed. 51, 12504–12508 (2012).
Eelkema, R. et al. Molecular machines: nanomotor rotates microscale objects. Nature 440, 163 (2006).
Bernà, T. J. et al. Macroscopic transport by synthetic molecular machines. Nature Mater. 4, 704–710 (2005).
Huang, J. et al. A nanomechanical device based on linear molecular motors. Appl. Phys. Lett. 85, 5391–5393 (2004).
Browne, W. R. & Feringa, B. L. Making molecular machines work. Nature Nanotech. 1, 25–35 (2006).
Feringa, B. L. & Browne, W. R. Macromolecules flex their muscles. Nature Nanotech. 3, 383–384 (2008).
Klok, M. et al. MHz unidirectional rotation of molecular rotary motors. J. Am. Chem. Soc. 130, 10484–10485 (2008).
London, G. et al. Light-driven altitudinal molecular motors on surfaces. Chem. Commun. 1712–1714 (2009).
Pollard, M. M. et al. Light-driven rotary molecular motors on gold nanoparticles. Chem. Eur. J. 14, 11610–11622 (2008).
Shimamura, M. K., Kamata, K., Yao, A. & Degushi, T. Scattering functions of knotted ring polymers. Phys. Rev. E 72, 041804 (2005).
Klok, M. et al. New mechanistic insight in the thermal helix inversion of second generation molecular motors. Chem. Eur. J. 14, 1183–11193 (2008).
Cnossen, A., Kistemaker, J. C. M., Kojima, T. & Feringa, B. L. Structural dynamics of overcrowded alkene-based molecular motors during thermal isomerization. J. Org. Chem. 79, 927–935 (2014).
Klok, M. Motors for Use in Molecular Nanotechnology PhD thesis, Univ. Groningen (2009).
Chen, J., Kistemaker, J. C. M., Robertus, J. & Feringa, B. L. Molecular stirrers in action. J. Am. Chem. Soc. 136, 14924–14932 (2014).
De Gennes, P-G. Scaling Concepts in Polymer Physics (Cornell Univ. Press, 1979).
Yamada, M. et al. Photomobile polymer materials: towards light-driven plastic motors. Angew. Chem. Int. Ed. 47, 4986–4988 (2008).
Ube, U. & Ikeda, T. Photomobile polymer materials with crosslinked liquid-crystalline structures: molecular design, fabrication, and function. Angew. Chem. Int. Ed. 53, 10290–10299 (2014).
Acknowledgements
The research leading to these results received funding from the European Research Council under the European Community's Seventh Framework Program (FP7/2007-2013)/ERC Starting Grant agreement no. 257099 (N.G.). The authors thank ANR (project INTEGRATIONS) for financial support. The authors acknowledge the Centre National de la Recherche Scientifique (CNRS), the COST action (CM 1304), the International Center for Frontier Research in Chemistry (icFRC), the Laboratory of Excellence for Complex System Chemistry (LabEx CSC), the University of Strasbourg (UdS) and the Institut Universitaire de France (IUF). Q.L. acknowledges the China Scholarship Council (CSC) for a doctoral fellowship. The authors also thank M. Archimbaud for HPLC purifications, G. Fleith for SAXS experiments, as well as R. Liu and T. Ellis for technical help at various stages.
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N.G. directed the work. G.F., E.M., I.K. and N.G. conceived the work. Q.L., G.F., E.M. and N.G. designed the synthesis. Q.L. and J.F. performed the synthesis and Q.L. performed the main chemical analyses and contraction experiments. M.M. performed AFM imaging. M.R. performed and analysed the X-ray scattering experiments. L.Q., M.R. and N.G. developed the contraction model. N.G. wrote the paper, and all authors commented on the manuscript.
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Li, Q., Fuks, G., Moulin, E. et al. Macroscopic contraction of a gel induced by the integrated motion of light-driven molecular motors. Nature Nanotech 10, 161–165 (2015). https://doi.org/10.1038/nnano.2014.315
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DOI: https://doi.org/10.1038/nnano.2014.315
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