Patients with rheumatoid arthritis who are hemiplegic, and also mice with denervated hindpaws and experimentally-induced arthritis, can develop unilateral arthritis. But is a specific branch of the nervous system involved in this asymmetry, or does a lack of innervation alter the microvasculature and promote vascular impermeability?
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A.E.K declares that she is a Senior Medical Fellow at Eli Lilly and Company. B.J.R. declares no competing interests.
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Rabquer, B., Koch, A. Microvascular clues to hemiplegia-induced asymmetric RA. Nat Rev Rheumatol 10, 701–702 (2014). https://doi.org/10.1038/nrrheum.2014.159
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DOI: https://doi.org/10.1038/nrrheum.2014.159