Sequencing studies demonstrate a strong clinical association between clonal haematopoiesis driven by acquired mutations and atherosclerotic disease. Previous research supports the idea that this association reflects a direct contribution of some clonal haematopoiesis-related mutations to atherosclerosis. Now, mathematical modelling suggests that atherosclerosis could instead accelerate clonal haematopoiesis.
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Acknowledgements
F.S.-C. is supported by the Spanish Ministerio de Ciencia e Innovación (grant RTI2018-102084-B-I00). J.J.F. is supported by the Ministerio de Ciencia e Innovación (grants RYC-2016-20026 and RTI2018-093554-A-I00), the Leducq Foundation (TNE-18CVD04), a 2019 Leonardo Grant for Researchers and Cultural Creators from the BBVA Foundation, and the European Research Area Network on Cardiovascular Diseases CHEMICAL (grant AC19/00133 from the Spanish “Instituto de Salud Carlos III”). The Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by the “Instituto de Salud Carlos III” and the “Ministerio de Ciencia e Innovación”.
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Sánchez-Cabo, F., Fuster, J.J. Clonal haematopoiesis and atherosclerosis: a chicken or egg question?. Nat Rev Cardiol 18, 463–464 (2021). https://doi.org/10.1038/s41569-021-00554-z
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DOI: https://doi.org/10.1038/s41569-021-00554-z
