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T-cell-depleted stem cell boost for the treatment of autoimmune haemolytic anaemia after T-cell-depleted allogeneic bone marrow transplantation complicated by adenovirus infection

Bone Marrow Transplantation volume 37, pages 977–978 (2006)Cite this article

Delayed and poor engraftment is a well-known complication after T-cell-depleted allogeneic BMT and may favour a transient immune system imbalance with delayed reconstitution of T-cell immunity.1, 2

Here we describe a 16-year-old patient who developed adenovirus infection followed by severe warm-type autoimmune haemolytic anaemia (wAIHA) after allogeneic unrelated T-cell-depleted BMT. The patient was diagnosed with hypoplastic myelodysplastic syndrome in May 2000 and had initially been treated with steroids. Owing to the lack of a suitable stem cell donor, he was transfused with platelet concentrates and packed red blood cells (RBCs).

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References

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Authors and Affiliations

  1. Division of Haematology and Oncology, Department of Internal Medicine, University of Rostock, Rostock, Germany

    I Hilgendorf, D Wolff, S Wilhelm, B Steiner, C Junghanss, M Freund & J Casper

  2. Division of Transfusion Medicine, Department of Internal Medicine, University of Rostock, Rostock, Germany

    V Kiefel

  3. Division of Nephrology, Department of Internal Medicine, University of Rostock, Rostock, Germany

    H Hickstein

Authors
  1. I Hilgendorf
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  2. D Wolff
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  3. S Wilhelm
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  4. B Steiner
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  5. V Kiefel
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  6. H Hickstein
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  7. C Junghanss
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  8. M Freund
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  9. J Casper
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Hilgendorf, I., Wolff, D., Wilhelm, S. et al. T-cell-depleted stem cell boost for the treatment of autoimmune haemolytic anaemia after T-cell-depleted allogeneic bone marrow transplantation complicated by adenovirus infection. Bone Marrow Transplant 37, 977–978 (2006). https://doi.org/10.1038/sj.bmt.1705356

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  • DOI: https://doi.org/10.1038/sj.bmt.1705356

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