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Allografting

Haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion for the treatment of hematological malignancies

Bone Marrow Transplantation volume 38, pages 291–297 (2006)Cite this article

A Corrigendum to this article was published on 27 August 2008

Abstract

Many patients who require allogeneic hematopoietic stem cell transplantation (allo-HSCT) lack a human leukocyte antigen (HLA)-matched donor. Here, we report a protocol for haploidentical allo-HSCT that combines granulocyte-colony stimulating factor primed bone marrow (G-BM) and peripheral blood stem cells (PBSC) without in vitro T-cell depletion (TCD). In this study, 171 patients, including 86 in high-risk group, underwent transplantation from haploidentical family donors. All patients achieved sustained, full donor chimerism. One hundred and eleven patients were alive in remission at a median of 682 (253–1502) days. The cumulative incidence of grade III–IV acute graft-versus-host disease (GVHD) was 23% and that of extensive chronic GVHD, 47%; these were not influenced by HLA disparity. Patients younger than 15 years had less grade III–IV acute GVHD than older patients (P=0.044). The 2-year probability of relapse was 12% for standard-risk disease and 39% for high-risk disease. The 2-year probability of leukemia-free survival (LFS) was 68% for standard-risk patients and 42% for high-risk patients (P=0.0009). Grade III–IV acute GVHD was associated with better LFS (P=0.0017). The results require confirmation and show that G-BM combined with PBSC from haploidentical family donors, without in vitro TCD, may be used as a good source of stem cells for allo-HSCT.

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Acknowledgements

This study was supported by Program for New Century Excellent Talents in Ministry of Education, National Natural Science Foundation of China, Peking University ‘211’ Program and Foundation of Chinese Ministry of Health.

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Authors and Affiliations

  1. Peking University Institute of Hematology, People's Hospital, Beijing, PRC

    X-J Huang, D-H Liu, K-Y Liu, L-P Xu, H Chen, W Han, Y-H Chen, J-Z Wang, Z-Y Gao, Y-C Zhang, Q Jiang, H-X Shi & D-P Lu

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  1. X-J Huang
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Correspondence to X-J Huang.

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Huang, XJ., Liu, DH., Liu, KY. et al. Haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion for the treatment of hematological malignancies. Bone Marrow Transplant 38, 291–297 (2006). https://doi.org/10.1038/sj.bmt.1705445

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