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Prevalence and correlates of orthostatic hypotension in middle-aged men and women in Korea: the Korean Health and Genome Study

Journal of Human Hypertension volume 18, pages 717–723 (2004)Cite this article

Abstract

To examine the prevalence and correlates of orthostatic hypotension (OH) in middle-aged adults enrolled in the Korean Health and Genome Study. Participants were 8908 individuals aged 40–69 years. Supine blood pressure (BP) was measured three times at 30-s intervals after at least 5 min of rest in the supine position and single standing BP was measured at 0 and 2 min after standing, respectively. OH was defined as a reduction in systolic BP or diastolic BP⩾20 and 10 mmHg, respectively. The prevalence of OH at 0 and 2 min after standing was 12.3 and 2.9%, respectively. At 0 min of standing, OH frequency increased significantly with age from 6.4% in those aged 40–44 years to 23.1% in those aged 65–69 (P<0.001). After adjustment for age and other characteristics, hypertension was associated with a 1.7-fold excess in the odds of OH in men and a 1.6-fold excess in women (P<0.001). In contrast, an increase in body mass index (BMI) on the order of 5 kg/m2 was associated with a 20–30% reduction in the odds of OH (P<0.001). Diabetes in women was also associated with a 1.4-fold excess in the odds of OH (P<0.05). An increase in triglyceride by 136 mg/dl in men was associated with an increase in the odds of OH (P<0.05). In conclusion, the prevalence and correlates of OH other than diabetes and triglycerides were notably similar in men and women. While the association between hypertension and OH has been observed elsewhere, low BMI in Korean adults with OH may be an important marker for subclinical morbidity or coexisting risk factors that need to be identified.

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Acknowledgements

We thank Jung Bok Lee from the Institute of Statistics at Korea University for valuable statistical guidance. The study was supported by a grant from the Korean National Institute of Health (government budget code 348-6111-221).

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Authors and Affiliations

  1. Institute of Human Genomic Study, Ansan Hospital, Korea University Medical School, Gyeonggi-do, Korea

    C Shin, H Lee & J Kim

  2. Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, VA, USA

    R D Abbott

  3. Korean National Genome Institute, Seoul, Korea

    K Kimm

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  1. C Shin
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  2. R D Abbott
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Correspondence to K Kimm.

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Supported by a grant from the Korean National Institute of Health (Government budget code 348-6111-221).

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Shin, C., Abbott, R., Lee, H. et al. Prevalence and correlates of orthostatic hypotension in middle-aged men and women in Korea: the Korean Health and Genome Study. J Hum Hypertens 18, 717–723 (2004). https://doi.org/10.1038/sj.jhh.1001732

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