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Amplification of AML1 in acute lymphoblastic leukemia is associated with a poor outcome

Leukemia volume 17, pages 2249–2250 (2003)Cite this article

TO THE EDITOR

Recently, we confirmed that partial duplication of the long arm of chromosome 21, dup(21), including the 21q22 chromosomal region and amplification of AML1, is a recurring chromosomal abnormality in acute lymphoblastic leukemia (ALL). Multiple copies of the AML1 gene were identified in 20 patients during routine screening by interphase fluorescence in situ hybridization (FISH) for the presence of the TEL/AML1 fusion.1 Together with the sporadic cases reported in the literature, our study raised the total number of published cases to 30. We now report a further eight patients with the same abnormality and comment on the survival of the 28 patients from our original series.

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References

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Acknowledgements

We thank the Leukaemia Research Fund for financial support; Dr Anne Hagermeijer (EU Concerted Action) and Dr Roland Berger (Paris) for cosmids ICRF c103C0664 and H11086, respectively; Dr John Crolla and his team, Wessex Regional Genetics Laboratory, Salisbury, for growing and preparation of the AML1-specific cosmids; the Clinical Trial Service Unit (CTSU), Oxford, for clinical and survival data. We are grateful to the following UKCCG cytogenetic laboratories for providing cytogenetic and FISH data as well as fixed cell suspensions: West Midlands Regional Genetics Services, Birmingham Women's Hospital; Haematology Cytogenetics Laboratory, University Hospital of Wales, Cardiff; SE Scotland Cytogenetics Services, Western General Hospital, Edinburgh; LRF Centre for Childhood Leukemia, Great Ormond Street Hospital, London; Cytogenetics Department, St James Hospital, Leeds; Merseyside & Cheshire Genetics Laboratory, Liverpool Women's Hospital, Liverpool; Oncology Cytogenetics Service, Christie Hospital, Manchester; North Trent Cytogenetics Service, Sheffield Children's Hospital NHS Trust, Sheffield.

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Authors and Affiliations

  1. Cancer Sciences Division, Leukaemia Research Fund Cytogenetics Group, University of Southampton, Southampton, UK

    H M Robinson, Z J Broadfield, K L Cheung, L Harewood, R L Harris, G R Jalali, M Martineau, A V Moorman, K E Taylor & C J Harrison

  2. Clinical Trial Service Unit, Radcliffe Infirmary, Oxford, UK

    S Richards

  3. Paediatric Oncology, John Radcliffe Hospital, Oxford, UK

    C Mitchell

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  1. H M Robinson
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  2. Z J Broadfield
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  4. L Harewood
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  5. R L Harris
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  6. G R Jalali
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Robinson, H., Broadfield, Z., Cheung, K. et al. Amplification of AML1 in acute lymphoblastic leukemia is associated with a poor outcome. Leukemia 17, 2249–2250 (2003). https://doi.org/10.1038/sj.leu.2403140

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  • DOI: https://doi.org/10.1038/sj.leu.2403140

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