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An international database and integrated analysis tools for the study of cancer gene expression

The Pharmacogenomics Journal volume 2, pages 156–164 (2002)Cite this article

Abstract

Researchers working collaboratively in Brazil and the United States have assembled an International Database of Cancer Gene Expression. Several strategies have been employed to generate gene expression data including expressed sequence tags (ESTs), serial analysis of gene expression (SAGE), and open reading-frame expressed sequence tags (ORESTES). The database contains six million gene tags that reflect the gene expression profiles in a wide variety of cancerous tissues and their normal counterparts. All sequences are deposited in the public databases, GenBank and SAGEmap. A suite of informatics tools was designed to facilitate in silico analysis of the gene expression datasets and are available through the NCI Cancer Genome Anatomy Project web site (http://cgap.nci.nih.gov).

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Acknowledgements

The Human Cancer Genome Project was supported by the Ludwig Institute for Cancer Research (LICR) and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). The ORESTES sequences were generated by a virtual network of 33 laboratories from the State of São Paulo, Brazil.

The NCI Cancer Genome Anatomy Project results from the effort of a multidisciplinary team of scientists from academic and industrial laboratories. A list of the CGAP team members can be found at URL:http://cgap.nci.nih.gov/Info/teams

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Authors and Affiliations

  1. National Cancer Institute, Bethesda, MD, USA

    R L Strausberg, C F Schaefer, L H Grouse, K H Buetow & S F Greenhut

  2. Ludwig Institute for Cancer Research, São Paulo, Brazil

    A A Camargo, S J de Souza & A J G Simpson

  3. Duke University Medical Center, Durham, NC, USA

    G J Riggins, A Lal & K Boon

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  1. R L Strausberg
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  2. A A Camargo
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  3. G J Riggins
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  4. C F Schaefer
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  5. S J de Souza
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  6. L H Grouse
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  7. A Lal
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  8. K H Buetow
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  10. S F Greenhut
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  11. A J G Simpson
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Correspondence to R L Strausberg.

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Strausberg, R., Camargo, A., Riggins, G. et al. An international database and integrated analysis tools for the study of cancer gene expression. Pharmacogenomics J 2, 156–164 (2002). https://doi.org/10.1038/sj.tpj.6500103

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