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Fine-mapping butyrophilin family genes revealed several polymorphisms influencing viral genotype selection in hepatitis C infection

Genes & Immunity volume 16, pages 297–300 (2015)Cite this article

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Abstract

Host–viral genetic interaction has a key role in hepatitis C infection (HCV) and maybe in the viral selection. In a preliminary GWAS analysis, we identified BTN3A2 rs9104 to be associated with HCV genotype 1. Therefore, our aim was to determine the influence of BTN family on the selection of HCV genotype. We performed a fine-mapping analysis of BTN gene region in a cohort of chronic HCV infection (N=841), validating significant results in another independent chronic HCV infection cohort (N=637), according to selection of viral genotype. BTN3A2 rs9104, BTN3A2 rs733528, BTN2A1 rs6929846, BTN2A1 rs7763910 and BTN3A3 rs13220495 were associated with viral genotype selection. Interestingly, BTN3A2 rs9104 GG genotype was closely related to genotype 1 infection (80.7% (394/488) compared with genotype 3 infection (53.5% (23/43); P=0.0001) in patients harboring IL28B-CT/TT genotype, although this effect was not observed in IL28B-CC genotype. Similarly, BTN3A3 rs13220495 CC genotype was linked to genotype 3 infection (100% (32/32)) compared to genotype 1 (87.3% (137/157); P=0.028) in patients harboring IL28B-CC genotype, but did not in IL28B-CT/TT genotype. Genetic variants in the butyrophilin family genes may alter susceptibility to infection, selecting HCV genotype and influencing disease progression. BTN3A2 rs9104 was strongly associated with genotype 1 infection and the haplotype BTN3A3 rs13220495 CC+IL28B genotype CC was universal in patients with hepatitis C genotype 3a.

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Acknowledgements

This work has been supported by Grant #P013/01192 of the Instituto de Salud Carlos III of the Spanish Government.

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Author notes

  1. J Ampuero, J A del Campo and L Rojas: These authors contributed equally to this work.

Authors and Affiliations

  1. Unit for the Clinical Management of Digestive Diseases and CIBERehd, Valme University Hospital, Sevilla, Spain

    J Ampuero, J A del Campo, L Rojas, M García-Valdecasas, Á Rojas, R Millán & M Romero-Gómez

  2. Immunology Unit, Hospital Universitario Virgen del Rocío, Sevilla, Spain

    R J García-Lozano & M F González-Escribano

  3. Hepatology Unit, Hospital Vall d’Hebron and CIBERehd, Barcelona, Spain

    M Buti

  4. Digestive Department, Hospital del Mar, Barcelona, Spain

    R Solá

  5. Liver Unit and IDIBAPS, Hospital Clinic and CIBERehd, Barcelona, Spain

    X Forns

  6. Digestive Department, Hospital de la Princesa, Madrid, Spain

    R Moreno-Otero

  7. Gastroenterology Department, Hospital Virgen de la Victoria and CIBERehd, Málaga, Spain

    R Andrade

  8. Digestive Department, Hospital General de Valencia, Valencia, Spain

    M Diago

  9. Digestive Department, Hospital Universitario San Cecilio and CIBERehd, Granada, Spain

    J Salmerón

  10. Gastroenterology Department, Hospital Central de Asturias, Oviedo, Spain

    L Rodrigo

  11. Gastroenterology Department, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain

    J A Pons

  12. Gastroenterology Department, Hospital Costa del Sol, Marbella, Spain

    J M Navarro

  13. Liver Unit, Hospital Puerta de Hierro, Madrid, Spain

    J L Calleja

  14. Hepatology Unit, Hospital Carlos III & CIBERehd, Madrid, Spain

    J García-Samaniego

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  1. J Ampuero
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  17. M García-Valdecasas
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  18. Á Rojas
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  19. R Millán
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  20. M F González-Escribano
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  21. M Romero-Gómez
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Corresponding author

Correspondence to M Romero-Gómez.

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The authors declare no conflict of interest.

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Ampuero, J., del Campo, J., Rojas, L. et al. Fine-mapping butyrophilin family genes revealed several polymorphisms influencing viral genotype selection in hepatitis C infection. Genes Immun 16, 297–300 (2015). https://doi.org/10.1038/gene.2015.14

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