Research ArticleCompartment- and context-specific changes in tissue-type plasminogen activator (tPA) activity following brain injury and pharmacological stimulation
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KEYWORDS
alzheimer's disease
amidolytic assay
head trauma
morphine
seizure
spinocerebellar ataxia
stroke
tissue-type plasminogen activator
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Supplementary Information accompanies the paper on the Laboratory Investigation website
Maithili Sashindranath and Andre Laval Samson: These authors contributed equally to this work.
Alterations in tissue-type plasminogen activator (tPA), a major protease of the central nervous system, may be a biomarker for perturbations in brain homeostasis. Differences in net tPA activity in the cerebral cortex, sub-cortical structures and cerebellum in wild type and tPA-/- mice, and in transgenic mice selectively overexpressing tPA in neurons are demonstrated.
Supplementary information The online version of this article (doi:10.1038/labinvest.2011.67) contains supplementary material, which is available to authorized users.
© 2011 United States & Canadian Academy of Pathology.