This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia
Leukemia Open Access 11 April 2016
-
Next Generation Sequencing of Acute Myeloid Leukemia: Influencing Prognosis
BMC Genomics Open Access 15 January 2015
-
Acute promyelocytic leukemias share cooperative mutations with other myeloid-leukemia subgroups
Blood Cancer Journal Open Access 13 September 2013
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
de Thé H, Chomienne C, Lanotte M, Degos L, Dejean A . The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus. Nature 1990; 347: 558–561.
Zimonjic DB, Pollock JL, Westervel P, Popescu NC, Ley TJ . Acquired, nonrandom chromosomal abnormalities associated with the development of acute promyelocytic leukemia in transgenic mice. Proc Natl Acad Sci 2000; 97: 13306–13311.
Akagi T, Shih LY, Kato M, Kawamata N, Yamamoto G, Sanada M et al. Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations. Blood 2009; 113: 1741–1748.
Kelly LM, Kutok JL, Williams IR, Boulton CL, Amaral SM, Curley DP et al. PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model. Proc Natl Acad Sci USA 2002; 99: 8283–8288.
Greif PA, Eck SH, Konstandin NP, Benet-Pages A, Ksienzyk B, Dufour A et al. Identification of recurring tumor-specific somatic mutations in acute myeloid leukemia by transcriptome sequencing. Leukemia 2011; 25: 821–827.
Ghavamzadeh A, Alimoghaddam K, Ghaffari SH, Rostami S, Jahani M, Hosseini R et al. Treatment of acute promyelocytic leukemia with arsenic trioxide without ATRA and/or chemotherapy. Ann Oncol 2006; 17: 131–134.
Ley TJ, Mardis ER, Ding L, Fulton B, McLellan MD, Chen K et al. DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature 2008; 456: 66–72.
Mardis ER, Ding L, Dooling DJ, Larson DE, McLellan MD, Chen K et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med 2009; 361: 1058–1066.
Paschka P, Marcucci G, Ruppert AS, Whitman SP, Mrozek K, Maharry K et al. Wilms′ tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study. J Clin Oncol 2008; 26: 4595–4602.
Chan IT, Kutok JL, Williams IR, Cohen S, Moore S, Shigematsu H et al. Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease. Blood 2006; 108: 1708–1715.
Eklund EA . The role of HOX genes in malignant myeloid disease. Curr Opin Hematol 2007; 14: 85–89.
Okamoto M, Hayakawa F, Miyata Y, Watamoto K, Emi N, Abe A et al. Lyn is an important component of the signal transduction pathway specific to FLT3/ITD and can be a therapeutic target in the treatment of AML with FLT3/ITD. Leukemia 2007; 21: 403–410.
Tomasson MH, Xiang Z, Walgren R, Zhao Y, Kasai Y, Miner T et al. Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia. Blood 2008; 111: 4797–4808.
Chun EM, Park YJ, Kang HS, Cho HM, Jun DY, Kim YH . Expression of the apolipoprotein C-II gene during myelomonocytic differentiation of human leukemic cells. J Leukoc Biol 2001; 69: 645–650.
Weinberg JB, Volkheimer AD, Mihovilovic M, Jiang N, Chen Y, Bond K et al. Apolipoprotein E genotype as a determinant of survival in chronic lymphocytic leukemia. Leukemia 2008; 22: 2184–2192.
Acknowledgements
This work was funded by a Deutsche Krebshilfe grant (109031) to PAG and SKB, and a grant from the BMBF to SKB (NGFN Plus, PKL-01-GS0876-6).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Additional information
Supplementary Information accompanies the paper on the Leukemia website
Supplementary information
Rights and permissions
About this article
Cite this article
Greif, P., Yaghmaie, M., Konstandin, N. et al. Somatic mutations in acute promyelocytic leukemia (APL) identified by exome sequencing. Leukemia 25, 1519–1522 (2011). https://doi.org/10.1038/leu.2011.114
Published:
Issue Date:
DOI: https://doi.org/10.1038/leu.2011.114
This article is cited by
-
Cytogenetics analysis as the central point of genetic testing in acute myeloid leukemia (AML): a laboratory perspective for clinical applications
Clinical and Experimental Medicine (2022)
-
A comprehensive review of genetic alterations and molecular targeted therapies for the implementation of personalized medicine in acute myeloid leukemia
Journal of Molecular Medicine (2020)
-
The genetics and clinical characteristics of children morphologically diagnosed as acute promyelocytic leukemia
Leukemia (2019)
-
Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia
Leukemia (2016)
-
Next Generation Sequencing of Acute Myeloid Leukemia: Influencing Prognosis
BMC Genomics (2015)